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2014 | 12 | 1 | 80-89
Tytuł artykułu

Stress degradation study of two oral antidiabetics, gliclazide and glipizide, and chemical analysis by LC and LC/MS methods

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Kinetic study of degradation of two oral antidiabetics, gliclazide and glipizide, was performed using new HPLC method which was validated in terms of selectivity, sensitivity, linearity, precision and accuracy. The stress degradation was performed in 0.2 M HCl, 0.2 M NaOH as well as in acetate and phosphate buffers over the pH range 3.8–8.3 at 30 and 70°C. In strong acidic and alkaline media gliclazide was almost fully degraded while glipizide showed much higher stability. Generally, degradation processes of gliclazide and glipizide were observed as the first order reactions while the rates of decomposition for both drugs were smallest at pH 8.3. The samples of gliclazide and glipizide stressed in strong acid and alkali at 70°C were additionally analyzed using an LC/MS method and some products of decomposition were detected and identified. It was concluded that glipizide was more resistant to very high or very low pH and would have higher stability compared to gliclazide. Such comparisons have not been performed so far for these valuable drugs. Additional LC/MS study showed that during decomposition of sulfonylureas, different degradation pathways were possible. [...]
Wydawca

Czasopismo
Rocznik
Tom
12
Numer
1
Strony
80-89
Opis fizyczny
Daty
wydano
2014-01-01
online
2013-10-27
Twórcy
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090, Lublin, Poland, anna.gumieniczek@umlub.pl
autor
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090, Lublin, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090, Lublin, Poland
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0355-8
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