Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments

• Autorzy: Georgeta Voicu , Ruxandra Geanaliu , Cristina Ghiţulică , Anton Ficai , Alexandru Grumezescu , Coralia Bleotu
• Języki publikacji: EN

Abstrakty

EN

The purpose of the present study is the preparation and characterization of collagen/antitumor drug hybrids as drug delivery systems. Materials used for obtaining collagen-based drug delivery systems were collagen type I (Coll) as matrix and irinotecan (I) as hydrophilic active substances. After incorporation of I into Coll in differing ratios, the obtained hybrid materials (Coll/I) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues or bone. The released amount of I varies with amount of Coll from hybrid materials: the higher, the slower the release amount of irinotecan transferred is in the first 6 hours. The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments. [...]

Słowa kluczowe

EN

Collagen; Irinotecan; Hybrid materials; Drug delivery system

• Czasopismo: Open Chemistry
• Rocznik: 2013
• Tom: 11
• Numer: 12
• Strony: 2134-2143

Daty

wydano

2013-12-01

online

2013-09-26

Twórcy

autor

Georgeta Voicu

• Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania

autor

Ruxandra Geanaliu

• Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania

autor

Cristina Ghiţulică

• Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania,

autor

Anton Ficai

• Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania

autor

Alexandru Grumezescu

• Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania

autor

Coralia Bleotu

• S. Nicolau Institute of Virology, 030304, Bucharest, Romania

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Identyfikatory

DOI

10.2478/s11532-013-0341-1