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2013 | 11 | 12 | 2076-2087
Tytuł artykułu

Simultaneous chiral separation and determination of carvedilol and 5′-hydroxyphenyl carvedilol enantiomers from human urine by high performance liquid chromatography coupled with fluorescent detection

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Języki publikacji
EN
Abstrakty
EN
A sensitive and specific high performance liquid chromatography coupled with fluorescent detection (HPLC-FL) and tandem mass spectrometry detection (HPLC-MS/MS) methods for separation and determination of carvedilol (CAR) enantiomers and 5′-hydroxyphenyl carvedilol (5′-HCAR) enantiomers has been developed and validated. The analysed compounds were extracted from human urine by solid phase extraction. Good enantioseparation of the studied enantiomers was achieved on CHIRALCEL® OD-RH column using 0.05% trifluoroacetic acid and 0.05% diethylamine in water and acetonitrile in a gradient elution. The mass spectrometric data were acquired using the multiple reaction monitoring mode by positive electrospray ionisation. The method was validated over the concentration range from 25.0 ng mL−1 to 200 ng mL−1 for the analysed compounds. The limit of quantification varied from 14.2 ng mL−1 to 24.2 ng mL−1. Both the repeatability and inter-day precisions were below 10.0%, and the accuracy varied from −13.2% to 3.77%. The extraction recoveries ranged from 79.2% to 108%. The present paper reports the method for the simultaneous determination of CAR enantiomers and their metabolite enantiomers (5′-HCAR) in human urine samples. This newly developed method was successfully used to analyse the aforementioned analytes in human urine samples obtained from patients suffering from cardiovascular disease. [...]
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
12
Strony
2076-2087
Opis fizyczny
Daty
wydano
2013-12-01
online
2013-09-26
Twórcy
  • Department of Analytical Chemistry, Silesian University of Technology, 44-100, Gliwice, Poland, sylwia.magiera@polsl.pl
  • Department of Analytical Chemistry, Silesian University of Technology, 44-100, Gliwice, Poland
  • Department of Analytical Chemistry, Silesian University of Technology, 44-100, Gliwice, Poland
Bibliografia
  • [1] W.H. Frishman, N. Engel. J. Med. 339, 1759 (1998) http://dx.doi.org/10.1056/NEJM199812103392407[Crossref]
  • [2] W. Bartsch, G. Sponer, K. Strein, B. Müller-Beckmann, L. Kling, E. Böhm, U. Martin, H.O. Borbe, Eur. J. Clin. Pharmacol. 38, S104 (1990) http://dx.doi.org/10.1007/BF01409475[Crossref]
  • [3] G.L. Erny, A. Cifuentes, J. Pharm. Biomed. Anal. 40, 509 (2006) http://dx.doi.org/10.1016/j.jpba.2005.10.044[Crossref]
  • [4] K. Stoschitzky, G. Koshucharova, P. Lercher, R. Maier, A. Sakotnik, W. Klein, P.M. Liebmann, W. Lindner, Chirality 13, 342 (2001) http://dx.doi.org/10.1002/chir.1042[Crossref]
  • [5] K. Stoschitzky, G. Koshucharova, R. Zweiker, P. Lercher, R. Maier, W. Klein, S. Zitta, L. Gruber, G. Lamprecht, W. Lindner, Cardiovasc. Drugs Ther. 16, 133 (2002) http://dx.doi.org/10.1023/A:1015705516496[Crossref]
  • [6] A. Medvedovici, F. Albu, C. Georgita, D.I. Sora, T. Galaon, S. Udrescu, V. David, J. Chromatogr. B 850, 327 (2007) http://dx.doi.org/10.1016/j.jchromb.2006.12.004[Crossref]
  • [7] T.W.B. Gehr, D.M. Tenero, D.A. Boyle, Y. Qian, D.A. Sica, N.H. Shusterman, Eur. J. Clin. Pharmacol. 55, 269 (1999) http://dx.doi.org/10.1007/s002280050628[Crossref]
  • [8] M. Zakrzewski-Jakubiak, S. de Denus, M.-H. Leblanc, M. White, J. Turgeon, J. Pharm. Biomed. Anal. 52, 636 (2010) http://dx.doi.org/10.1016/j.jpba.2010.02.002[Crossref]
  • [9] M. Saito, J. Kawana, T. Ohno, M. Kaneko, K. Mihara, K. Hanada, R. Sugita, N. Okada, S. Oosato, M. Nagayama, T. Sumiyoshi, H. Ogata, J. Chromatogr. B 843, 73 (2006) http://dx.doi.org/10.1016/j.jchromb.2006.05.018[Crossref]
  • [10] R.G. Peccinini, V.F. Ximenes, E.J. Cesarino, V.L. Lanchote, Biopharm. Drug Dispos. 29, 280 (2008) http://dx.doi.org/10.1002/bdd.613[Crossref]
  • [11] G. Larnprecht, L. Gruber, K. Stoschitzky, W. Lindner, Chromatographia 56, S–25 (2002)
  • [12] L. Clohs, K.M. McErlane, J. Pharm. Biomed. Anal. 31, 407 (2003) http://dx.doi.org/10.1016/S0731-7085(02)00609-X[Crossref]
  • [13] E. Yang, S. Wang, J. Kratz, M.J. Cyronak, J. Pharm. Biomed. Anal. 36, 609 (2004) http://dx.doi.org/10.1016/j.jpba.2004.07.008[Crossref]
  • [14] E.J. Eisenberg, W.R. Patterson, G.C. Kahn, J. Chromatogr. B 493, 105 (1989) http://dx.doi.org/10.1016/S0378-4347(00)82713-9[Crossref]
  • [15] H. Spahn, W. Henke, P. Langguth, J. Schloos, E. Mutschler, Arch. Pharm. (Weinheim) 323, 465 (1990) http://dx.doi.org/10.1002/ardp.19903230805[Crossref]
  • [16] E. Stahl, E. Mutschler, U. Baumgartner, H. Spahn-Langguth, Arch. Pharm. (Weinheim) 326, 529 (1993) http://dx.doi.org/10.1002/ardp.19933260907[Crossref]
  • [17] G. Neugebauer, W. Akpan, B. Kaufmann, K. Reiff, Eur. J. Clin. Pharmacol. 38, S108 (1990) http://dx.doi.org/10.1007/BF01409476[Crossref]
  • [18] I. Baranowska, P. Markowski, J. Baranowski, Anal. Sci. 25, 1307 (2009) http://dx.doi.org/10.2116/analsci.25.1307[Crossref]
  • [19] M. Machida, M. Watanabe, S. Takechi, S. Kakinoki, A. Nomura, J. Chromatogr. B 798, 187 (2003) http://dx.doi.org/10.1016/j.jchromb.2003.09.039[Crossref]
  • [20] A. Zarghi, S.M. Foroutan, A. Shafaati, A. Khoddam, J. Pharm. Biomed. Anal. 44, 250 (2007) http://dx.doi.org/10.1016/j.jpba.2007.01.026[Crossref]
  • [21] N. Hokama, N. Hobara, H. Kameya, S. Ohshiro, M. Sakanashi, J. Chromatogr. B 732, 233 (1999) http://dx.doi.org/10.1016/S0378-4347(99)00248-0[Crossref]
  • [22] R. Rathod, P.Ch. Prasad, S. Rani, M. Nivsarkar, H. Padh, J. Chromatogr. B 857, 219 (2007) http://dx.doi.org/10.1016/j.jchromb.2007.07.021[Crossref]
  • [23] P. Ptáček, J. Macek, J. Klíma, J. Chromatogr. B 798, 405 (2003)
  • [24] M.P. McIntosh, B.J. Carlson, K.S. Schorno, R.A. Rajewski, J. Chromatogr. B 852, 665 (2007) http://dx.doi.org/10.1016/j.jchromb.2007.02.023[Crossref]
  • [25] D.W. Jeong, Y.H. Kim, H.Y. Ji, Y.S. Youn, K.Ch. Lee, H.S. Lee, J. Pharm. Biomed. Anal. 44, 547 (2007) http://dx.doi.org/10.1016/j.jpba.2006.12.017[Crossref]
  • [26] G. Lamprecht, K. Stoschitzky, Chromatographia 59, 551 (2004) http://dx.doi.org/10.1365/s10337-004-0275-z[Crossref]
  • [27] F. Behn, S. Läer, T.S. Mir, H. Scholz, Chromatographia 53, 641 (2001) http://dx.doi.org/10.1007/BF02493012[Crossref]
  • [28] H.H. Maurer, O. Tenberken, C. Kratzsch, A.A. Weber, F.T. Peters, J. Chromatogr. A 1058, 169 (2004)
  • [29] L. Kristoffersen, E.L. Øiestad, M.S. Opdal, M. Krogh, E. Lundanes, A.S. Christophersen, J. Chromatogr. B 850, 147 (2007) http://dx.doi.org/10.1016/j.jchromb.2006.11.030[Crossref]
  • [30] N.C. do Carmo Borges, G.D. Mendes, D. de Oliveira Silva, V.M. Rezende, R.E. Barrientos-Astigarraga, G.D. Nucci, J. Chromatogr. B 822, 253 (2005) http://dx.doi.org/10.1016/j.jchromb.2005.06.012[Crossref]
  • [31] S.W. Myung, Ch.H. Jo, J. Chromatogr. B 822, 70 (2005) http://dx.doi.org/10.1016/j.jchromb.2005.05.023[Crossref]
  • [32] S. Magiera, C. Uhlschmied, M. Rainer, Ch.W. Huck, I. Baranowska, G.K. Bonn, J. Pharm. Biomed. Anal. 56, 93 (2011) http://dx.doi.org/10.1016/j.jpba.2011.04.024[Crossref]
  • [33] F. Behn, S. Michels, S. Läer, G. Blaschke, J. Chromatogr. B 755, 111 (2001) http://dx.doi.org/10.1016/S0378-4347(01)00045-7[Crossref]
  • [34] I. Baranowska, S. Magiera, J. Baranowski, J. Chromatogr. B 879, 615 (2011) http://dx.doi.org/10.1016/j.jchromb.2011.01.026[Crossref]
  • [35] P. Konieczka, Crit. Rev. Anal. Chem. 37, 173 (2007) http://dx.doi.org/10.1080/10408340701244649[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0329-x
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