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2013 | 11 | 12 | 2040-2047
Tytuł artykułu

UV-absorption studies of interaction of karanjin and karanjachromene with ds. DNA: Evaluation of binding and antioxidant activity

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Two flavonoids, karanjin (Kj) and karanjachromene (Kc) have been investigated spectrophotometrically for their mode of interactions with double stranded (ds)-DNA at blood (7.4) and stomach (4.7) pH and at human body temperature (37°C). Benesi-Hildebrand equation was used to evaluate the binding constants, K b . Binding constants at both pH values and at body temperature showed stronger binding of both the flavonoids and formation of 1:1 flavonoid-DNA complex via intercalative mode. However, K b values for karanjin were evaluated to be comparatively greater than karanjachromene at both pH values. The highest value of binding constant (1.32×105 M−1) for karanjin at blood pH (7.4) demonstrated its comparatively stronger binding and greater effectiveness at this pH. Standard Gibbs free energy changes (ΔG) of flavonoid-DNA complexes were calculated as negative values and indicative of spontaneity of their binding. Both flavonoids showed significant DNA protection activity. [...]
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
12
Strony
2040-2047
Opis fizyczny
Daty
wydano
2013-12-01
online
2013-09-26
Twórcy
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan, nasimaa2006@yahoo.com
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan
autor
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan
  • Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
autor
  • Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0327-z
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