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2013 | 11 | 11 | 1837-1843
Tytuł artykułu

Differential pulse adsorptive stripping voltammetric determination of methotrexate using a functionalized carbon nanotubes-modified glassy carbon electrode

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A glassy carbon electrode (GC) containing multiwalled functionalized carbon nanotubes (MWCNTs) immobilized within a dihexadecylhydrogenphosphate film (DHP) is proposed as a nanostructured platform for determination of methotrexate (MTX) concentration (a drug used in cancer treatment) using differential pulse adsorptive stripping voltammetry (DPAdSV). The voltammograms for a MTX solution using MWCNTs-DHP/GC electrode presented an oxidation peak potential at 0.98 V vs. Ag/AgCl (3.0 mol L−1 KCl) in a 0.1 mol L−1 sulphuric acid. The apparent heterogeneous electron transfer rate constant of 0.46 s−1 was calculated. The recovery area of 2.62×10−9 mol cm2 was also obtained. Under the optimal experimental conditions, the analytical curve was linear in the MTX concentration range from 5.0×10−8 to 5.0×10−6 mol L−1, with a detection limit of 3.3×10−8 mol L−1. The MWCNTs-DHP/GC electrode can be easily prepared and was applied for the determination of MTX in pharmaceutical formulations, with results similar to those obtained using a high-performance liquid chromatography comparative method. [...]
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
11
Strony
1837-1843
Opis fizyczny
Daty
wydano
2013-11-01
online
2013-08-25
Twórcy
  • Department of Chemistry, Center for Science and Technology, Federal University of São Carlos, P. Box 676, 13560-970, São Carlos - SP, Brazil
  • Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, 13566-590, São Carlos - SP, Brazil
  • Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, 13566-590, São Carlos - SP, Brazil
  • Department of Chemistry, Center for Science and Technology, Federal University of São Carlos, P. Box 676, 13560-970, São Carlos - SP, Brazil, bello@ufscar.br
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0305-5
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