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2013 | 11 | 11 | 1757-1767
Tytuł artykułu

Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Eight hydrochlorides of 3-{2-[(2/4-fluorophenoxy)-ethylamino]}-2-hydroxypropyl-4-alkoxybenzoates and four hydrochlorides of 3-tert-butylamino-2-hydroxypropyl-4-butoxybenzoates were prepared as potential antagonists of the β1-adrenergic receptor (beta-blockers). A multistep synthesis of these compounds is described as well as their detailed analytical characterization. The pharmacokinetic properties of these weak base compounds are significantly influenced by their acid-base dissociation constant, pK a. The knowledge of this value is crucial for new drug development. This paper is aimed at developing a methodology that utilizes pH-dependent 1H NMR spectroscopy for its routine analysis. The selected predicted physico-chemical parameters of the new (arylcarbonyloxy)aminopropanols (i.e., aryloxyaminopropanol derivatives) were compared with the model drugs esmolol and flestolol. [...]
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
11
Strony
1757-1767
Opis fizyczny
Daty
wydano
2013-11-01
online
2013-08-25
Twórcy
  • Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical sciences Brno, 612 42, Brno, Czech Republic
  • Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical sciences Brno, 612 42, Brno, Czech Republic
autor
  • Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical sciences Brno, 612 42, Brno, Czech Republic
  • Global Change Research Centre AS CR, 603 00, Brno, Czech Republic
  • Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical sciences Brno, 612 42, Brno, Czech Republic
  • Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical sciences Brno, 612 42, Brno, Czech Republic
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0302-8
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