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2013 | 11 | 9 | 1548-1553
Tytuł artykułu

Characterization of polymeric system for cisplatin delivery - analytical methods for Pt determination

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Abstract Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed. Graphical abstract [...]
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
9
Strony
1548-1553
Opis fizyczny
Daty
wydano
2013-09-01
online
2013-06-29
Twórcy
  • Geological Institute, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria
autor
  • Institute of Polymers, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0278-4
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