Direct determination of enantiomeric enrichment of chiral, underivatized aminophosphonic acids - useful for enantioselective bioconversion results evaluation

• Autorzy: Kinga Kozyra , Magdalena Klimek-Ochab , Małgorzata Brzezińska-Rodak , Ewa Żymańczyk-Duda
• Języki publikacji: EN

Abstrakty

EN

Abstract The possibility of applying 31P NMR spectroscopy for the determination of the enantiomeric excess of the racemic mixture of non-derivatized aminophosphonic acids with small side chains has been investigated. It is proven, that the effectiveness of the application of a chiral solvating agent strongly depends on the concentration of applied shift reagent and on the pH of the particular experiment. Effectual resolution protocols are elaborated for following phosphonic acids: 1-aminoethanephosphonic acid, 1-amino-2-methylpropanephosphonic acid, 1-aminophenylmethanephosphonic acid, 1-aminophenylmethane-phosphonic acid and 1-amino-2-phenylethanephosphonic acid. Graphical abstract [...]

Słowa kluczowe

EN

NMR; Aminophosphonic acid; Enantiomeric excess; Chiral solvating agent

• Czasopismo: Open Chemistry
• Rocznik: 2013
• Tom: 11
• Numer: 9
• Strony: 1542-1547

Daty

wydano

2013-09-01

online

2013-06-29

Twórcy

autor

Kinga Kozyra

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland,

autor

Magdalena Klimek-Ochab

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland

autor

Małgorzata Brzezińska-Rodak

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland

autor

Ewa Żymańczyk-Duda

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland

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Identyfikatory

DOI

10.2478/s11532-013-0277-5