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2013 | 11 | 8 | 1309-1319
Tytuł artykułu

High resolution mass spectrometric characterization of amino linked oligosaccharides - a preliminary study

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In this study maltose, maltotriose and maltotetraose were for the first time, coupled to 4,4′-methylenedianiline (MDA). The aim of this preliminary work was to test the feasibility of oligo- and polysaccharide coupling to MDA and the characterization of the coupling products by high resolution mass spectrometry (MS). (+) nanoESI in combination with a quadrupole time of flight (QTOF) MS in full scan (MS) and MS/MS was optimized first on underivatized maltose, maltotriose and maltotetraose. The optimal screening and sequencing conditions were further applied to the MDA-functionalized oligosaccharides. The obtained results revealed a straightforward MS detection of the functionalized oligomers, high sequence coverage and a fragmentation pathway with the formation of B and Y ions as well as the complementary C and Z ions along with a typical cleavage of the aglycon. We consider that this methodology is fully applicable also to polydisperse mixtures of long chain polysaccharides, which due to the large number of components and their size require a systematic method of development and testing. [...]
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
8
Strony
1309-1319
Opis fizyczny
Daty
wydano
2013-08-01
online
2013-06-01
Twórcy
  • Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, 300041, Timisoara, Romania
autor
  • Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, 300041, Timisoara, Romania
autor
  • Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, 300041, Timisoara, Romania
Bibliografia
  • [1] D. L. Nelson, M.M. Cox, Lehninger Principles of Biochemistry, 4th edition (W.H. Freeman and Co., New York, 2005)
  • [2] S. Namkung, C.C. Chu, J. Biomater. Sci. Polym. 18, 901 (2007) http://dx.doi.org/10.1163/156856207781367701[Crossref]
  • [3] A. Abed, B. Deval, N. Assoul, I. Bataille, P. Portes, L. Louedec, D. Henin, D. Letourneur, A. Meddahi-Pellé, Tissue Eng. Part A 14, 519 (2008) http://dx.doi.org/10.1089/tea.2007.0134[Crossref]
  • [4] T. Zhang, R.E. Marchant, Macromolecules 27, 7302 (1994) http://dx.doi.org/10.1021/ma00103a011[Crossref]
  • [5] I. Bita, J.K. Yang, Y.S. Jung, C.A. Ross, E.L. Thomas, K.K. Berggren, Science 321, 939 (2008) http://dx.doi.org/10.1126/science.1159352[Crossref]
  • [6] C. T. Black, Nat. Nanotechnol. 2, 464 (2007) http://dx.doi.org/10.1038/nnano.2007.244[Crossref]
  • [7] R. Muppalla, S.K. Jewrajka, K. Prasad, J. Biomed. Mater Res. A. 101(6), 1637 (2012)
  • [8] S. J. Rezaei, M.R. Nabid, H. Niknejad, A.A. Entezami, Int. J. Pharm. 437(1–2), 70 (2012) http://dx.doi.org/10.1016/j.ijpharm.2012.07.069[Crossref]
  • [9] C. Hoskins, P.K. Thoo-Lin, W.P. Cheng, Ther. Deliv. 3(1), 59 (2012) http://dx.doi.org/10.4155/tde.11.130[Crossref]
  • [10] Q. Zhang, N.R. Ko, J.K. Oh, Chem. Commun. (Camb). 48(61), 7542 (2012) http://dx.doi.org/10.1039/c2cc32408c[Crossref]
  • [11] P. Tanner, P. Baumann, R. Enea, O. Onaca, C. Palivan, W. Meier, Acc. Chem. Res. 44(10), 1039 (2011) http://dx.doi.org/10.1021/ar200036k[Crossref]
  • [12] Y. R. Kim, S. Jung, H. Ryu, Y.E. Yoo, S.M. Kim, T.J. Jeon, Sensors (Basel) 12(7), 9530 (2012) http://dx.doi.org/10.3390/s120709530[Crossref]
  • [13] A. Doğan, M.E. Yalvaç, F. Şahin, A.V. Kabanov, A. Palotás, A.A. Rizvanov, Int. J. Nanomedicine 7, 4849 (2012)
  • [14] J. Tan, W.G. McClung, J.L. Brash, J. Biomed. Mater. Res. A. 85(4), 873 (2008) [Crossref]
  • [15] E. Sisu, W.T. Bosker, W. Norde, T.M. Slaghek, J.W. Timmermans, J. Peter Katalinić, M.A. Cohen-Stuart, A.D. Zamfir, Rapid Commun. Mass Spectrom. 20, 209 (2006) http://dx.doi.org/10.1002/rcm.2296[Crossref]
  • [16] I. Perdivara, E. Sisu, I. Sisu, N. Dinca, K.B. Tomer, M. Przybylski, A.D. Zamfir, Rapid Commun. Mass Spectrom. 22, 773 (2008) http://dx.doi.org/10.1002/rcm.3435[Crossref]
  • [17] I. Sisu, V. Udrescu, C. Flangea, S. Tudor, N. Dinca, L. Rusnac, A.D. Zamfir, E. Sisu, Cent. Eur. J. Chem. 7(1), 66 (2009) http://dx.doi.org/10.2478/s11532-008-0090-8[Crossref]
  • [18] J. Zaia, Mass Spectrom. Rev. 23, 161 (2004) http://dx.doi.org/10.1002/mas.10073[Crossref]
  • [19] B. Domon, C.E. Costello, Glycoconj. J. 5, 397 (1988) http://dx.doi.org/10.1007/BF01049915[Crossref]
  • [20] C. Flangea, E. Sisu, D.G. Seidler, A.D. Zamfir, Anal. Biochem. 420, 155 (2012) http://dx.doi.org/10.1016/j.ab.2011.08.052[Crossref]
  • [21] A. D. Zamfir, A. Serb, Ž. Vukelić, C. Flangea, C. Schiopu, D. Fabris, S. Kalanj-Bognar, F. Capitan, E. Sisu, J. Am. Soc. Mass Spectrom. 22, 2145 (2011) http://dx.doi.org/10.1007/s13361-011-0250-5[Crossref]
  • [22] C. Flangea, A. Serb, E. Sisu, A.D. Zamfir, Biochimica et Biophysica Acta 1811, 513 (2011) http://dx.doi.org/10.1016/j.bbalip.2011.06.008[Crossref]
  • [23] B. Stahl, M. Steup, M. Karras, F. Hillenkamp, Anal. Chem. 63(14), 1463 (1991) http://dx.doi.org/10.1021/ac00014a022[Crossref]
  • [24] M. J. Deery, E. Stimson, C.G. Chappell, Rapid Commun. Mass Spectrom. 15, 2273 (2001) http://dx.doi.org/10.1002/rcm.458[Crossref]
  • [25] A. Pfenninger, M. Karas, B. Finke, B. Stahl, J. Am. Soc. Mass Spectrom. 13(11), 1331 (2002) http://dx.doi.org/10.1016/S1044-0305(02)00645-1[Crossref]
  • [26] U. Bahr, A. Pfenninger, M. Karas, B. Stahl, Anal. Chem. 69(22), 4530 (1997) http://dx.doi.org/10.1021/ac970624w[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0265-9
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