A simple TLC and HPTLC method for separation of selected steroid drugs

• Autorzy: Joanna Nowakowska , Piotr Pikul , Krzesimir Ciura , Jakub Piotrowicz
• Języki publikacji: EN

Abstrakty

EN

Chromatographic properties of five steroid drugs: cortisone, hydrocortisone, methylprednisolone, prednisolone and norgestrel have been studied by normal-, reversed-phase and hydrophilic neutral cyano-bonded silica stationary phase with five binary mobile phases (acetonitrile-water, acetonitrile-DMSO, acetonitrile-methanol, acetone-petroleum ether, acetone-water) in which the concentration of organic modifier was varied from 0 to 100% (v/v). This study reports the optimization of steroid hormones separation. Chromatographic retention data and possible retention mechanisms are discussed. Separation abilities of mobile and stationary phases were studied using the principal component analysis method. The best separation of methylprednisolone and prednisolone is with a chromatographic system included silica gel as stationary phase and mixture of acetonitrile and DMSO (10:90 v/v). These two anti-inflammatory drugs can be fast separated from norgestrel when CN is used as stationary phase and acetone and water (40:60 v/v) as mobile phase. The highest values of the parameter Δ(ΔG°) and alfa for cortisone and hydrocortisone was observed in case of using CN as stationary phase and water-acetonitryle (40:60 v/v) as mobile phase. [...]

Słowa kluczowe

EN

Principal component analysis; Separation factor; Standard (Gibbs) free energy change of partition; Steroid drugs; Thin-layer chromatography

• Czasopismo: Open Chemistry
• Rocznik: 2013
• Tom: 11
• Numer: 8
• Strony: 1297-1308

Daty

wydano

2013-08-01

online

2013-06-01

Twórcy

autor

Joanna Nowakowska

• Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416, Gdańsk, Poland

autor

Piotr Pikul

• Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416, Gdańsk, Poland,

autor

Krzesimir Ciura

• Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416, Gdańsk, Poland

autor

Jakub Piotrowicz

• Department of Economics and Law, Maritime Institute in Gdańsk, 80-830, Gdańsk, Poland

Bibliografia

• [1] G. Streck, Trends Analyt. Chem. 28, 635 (2009) http://dx.doi.org/10.1016/j.trac.2009.03.006[Crossref]
• [2] R. Gupta, D.P. Jindal, G. Kumar, Bioorg. Med. Chem. 12, 6331 (2004) http://dx.doi.org/10.1016/j.bmc.2004.05.045[Crossref]
• [3] L. Gagliardi, D. De Orsi, M.R.D. Giudice, F. Gatta, R. Porrá, P. Chimenti, D. Tonelli, Anal. Chim. Acta 457, 187 (2002) http://dx.doi.org/10.1016/S0003-2670(02)00017-X[Crossref]
• [4] C. Baggiani, P. Baravalle, C. Giovannoli, L. Anfossi, G. Giraudi, Biosens. Bioelectron. 26, 590 (2010) http://dx.doi.org/10.1016/j.bios.2010.07.023[Crossref]
• [5] B. Marciniec, M. Ogrodowczyk, K. Dettlaff, Radiat. Phys. Chem. 72, 517 (2005) http://dx.doi.org/10.1016/j.radphyschem.2004.02.004[Crossref]
• [6] L. Gagliardi, D. De Orsi, M.R.D. Giudice, F. Gatta, R. Porrá, P. Chimenti, D. Tonelli, Anal. Chim. Acta 457, 187 (2002) http://dx.doi.org/10.1016/S0003-2670(02)00017-X[Crossref]
• [7] N. Klinsunthorn, A. Petsom, T. Nhujak, J. Pharm. Biomed. Anal. 55, 1175 (2011) http://dx.doi.org/10.1016/j.jpba.2011.03.046[Crossref]
• [8] V. L. Clifton, A. Bisits, P.K. Zarzycki, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 855, 249 (2007) http://dx.doi.org/10.1016/j.jchromb.2007.05.041[Crossref]
• [9] Y. Iglesias, C. Fente, B.I. Vázquez, C. Franco, A. Cepeda, S. Mayo, Anal. Chim. Acta 468, 43 (2002) http://dx.doi.org/10.1016/S0003-2670(02)00598-6[Crossref]
• [10] L. Ahonen, P. Keski-Rahkonen, T. Saarelainen, J. Paviala, R.A. Ketola, S. Auriola, M. Poutanen, R. Kostianen, Anal. Chim. Acta 721, 115 (2012) http://dx.doi.org/10.1016/j.aca.2012.01.039[Crossref]
• [11] O. Van Den Hauwe, F. Dumoulin, C. Elliott, C. Van Peteghem, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 817, 215 (2005) http://dx.doi.org/10.1016/j.jchromb.2004.12.006[Crossref]
• [12] H. -C. Zhang, X.-J. Yu, W.-C. Yang, J.-F. Peng, T. Xu, D.-Q. Yin, X.-L. Hu, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879, 2998 (2011) http://dx.doi.org/10.1016/j.jchromb.2011.08.036[Crossref]
• [13] I. A. Ionita, D.M. Fast, F. Akhlaghi, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 765 (2009) http://dx.doi.org/10.1016/j.jchromb.2009.02.019[Crossref]
• [14] J. H. Andersen, L.G. Hansen, M. Pedersen, Anal. Chim. Acta 617, 216 (2008) http://dx.doi.org/10.1016/j.aca.2008.02.070[Crossref]
• [15] O. Van Den hauwe, F. Dumoulin, J.P. Antignac, M.P. Bouche, C. Elliott, C. Van Peteghem, Anal. Chim. Acta 173, 127 (2002) http://dx.doi.org/10.1016/S0003-2670(02)00754-7[Crossref]
• [16] R. L. Jones, L.J. Owen, J.E. Adaway, B.G. Keevil, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 881–882, 42 (2012)
• [17] V. M Carvalho, O.H. Nakamura, J.G.H. Vieira, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 872, 154 (2008) http://dx.doi.org/10.1016/j.jchromb.2008.07.035[Crossref]
• [18] Y. Rönquist-Nii, P.O. Edlund, J. Pharm. Biomed. Anal. 37, 341 (2005) http://dx.doi.org/10.1016/j.jpba.2004.10.044[Crossref]
• [19] D. Chen, Y. Tao, Z. Liu, H. Zhang, Z. Liu, Y. Wang, L. Huang, Y. Pan, D. Peng, M. Dai, X. Wang, Z. Yuan, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879, 174 (2011) http://dx.doi.org/10.1016/j.jchromb.2010.11.039[Crossref]
• [20] I. Laverdière, P. Caron, F. Couture, E. Lévesque, C. Guillemette, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 885–886, 131 (2012)
• [21] G. Dusi, M. Gasparini, M. Curatolo, W. Assini, E. Bozzoni, N. Tognoli, E. Ferretti, Anal. Chim. Acta 700, 49 (2011) http://dx.doi.org/10.1016/j.aca.2011.01.011[Crossref]
• [22] N. H. Yu, E.N.M. Ho, F.P.W. Tang, T.S.M. Wan, A.S.Y. Wong, J. Chromatogr. A 1189, 426 (2008) http://dx.doi.org/10.1016/j.chroma.2007.11.022[Crossref]
• [23] X. Ding, M.J. Rose, I. McCaffery, J. Rossi, K. Paweletz, C. Hale, M. Emery, C.A. James, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 1394 (2009) http://dx.doi.org/10.1016/j.jchromb.2008.09.025[Crossref]
• [24] F. Bévalot, Y. Gaillard, M.A. Lhermitte, G. Pépin, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 740, 227 (2000) http://dx.doi.org/10.1016/S0378-4347(00)00085-2[Crossref]
• [25] M. H. Spyridaki, P. Kiousi, A. Vonaparti, P. Valavani, V. Zonaras, M. Zahariou, E. Sianos, G. Tsoupras, C. Georgakopoulos, Anal. Chim. Acta 573–574, 242 (2006) http://dx.doi.org/10.1016/j.aca.2006.04.042[Crossref]
• [26] Y. Yang, B. Shao, J. Zhang, Y. Wu, H. Duan, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 489 (2009) http://dx.doi.org/10.1016/j.jchromb.2008.12.054[Crossref]
• [27] Y. Deceuninck, E. Bichon, F. Monteau, J.-P. Antignac, B. Le Bizec, Anal. Chim. Acta 700, 137 (2011) http://dx.doi.org/10.1016/j.aca.2010.12.042[Crossref]
• [28] B. C Mcwhinney, S.E. Briscoe, J.P.J. Ungerer, C.J. Pretorius, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878, 2863 (2010) http://dx.doi.org/10.1016/j.jchromb.2010.08.044[Crossref]
• [29] Y. Deceuninck, E. Bichon, F. Monteau, J.-P. Antignac, B. Le Bizec, Anal. Chim. Acta 700, 137 (2011) http://dx.doi.org/10.1016/j.aca.2010.12.042[Crossref]
• [30] C. H.F. Wong, F.P.W. Tang, T.S.M. Wan, Anal. Chim. Acta 697, 48 (2011) http://dx.doi.org/10.1016/j.aca.2011.04.030[Crossref]
• [31] P. Herrero, F. Borrull, E. Pocurull, R.M. Marcé, J. Chromatogr. A 1224, 19 (2012) http://dx.doi.org/10.1016/j.chroma.2011.12.054[Crossref]
• [32] M. E. Touber, M.C. van Engelen, C. Georgakopoulus, J.A. van Rhijn, M.W.F. Nielen, Anal. Chim. Acta 586, 137 (2007) http://dx.doi.org/10.1016/j.aca.2006.09.058[Crossref]
• [33] S. Liu, G.-G. Ying, J.-L. Zhao, F. Chen, B. Yang, L.-J. Zhou, H.-J. Lai, J. Chromatogr. A 1218, 1367 (2011) http://dx.doi.org/10.1016/j.chroma.2011.01.014[Crossref]
• [34] H. Shibasaki, H. Nakayama, T. Furuta, Y. Kasuya, M. Tsuchiya, A. Soejima, A. Yamada, T. Nagasawa, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 870, 164 (2008) http://dx.doi.org/10.1016/j.jchromb.2008.03.003[Crossref]
• [35] L. Amendola, F. Garribba, F. Botrè, Anal. Chim. Acta 489, 233 (2003) http://dx.doi.org/10.1016/S0003-2670(03)00703-7[Crossref]
• [36] Y. W. Ha, J.-Y. Moon, H.-J. Jung, B.C. Chung, M.H. Choi, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 4125 (2009) http://dx.doi.org/10.1016/j.jchromb.2009.11.010[Crossref]
• [37] G. E. Guild, C.E. Lenehan, G.S. Walker, Int. J. Mass Spectrom. 294, 16 (2010) http://dx.doi.org/10.1016/j.ijms.2010.04.001[Crossref]
• [38] T. -C. Chiu, Talanta 86, 415 (2011) http://dx.doi.org/10.1016/j.talanta.2011.09.038[Crossref]
• [39] H. Sirén, T. Seppänen-Laakso, M. Orešič, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 871, 375 (2008). http://dx.doi.org/10.1016/j.jchromb.2008.06.016[Crossref]
• [40] P. Hommerson, A.M. Khan, G.J. de Jong, G.W. Somsen, J. Chromatogr. A 1204, 197 (2008) http://dx.doi.org/10.1016/j.chroma.2008.04.017[Crossref]
• [41] P. Zakaria, G.W. Dicinoski, B.K. Ng, R.A. Shellie, M. Hanna-Brown, P.R. Haddad, J. Chromatogr. A 1216, 6600 (2009) http://dx.doi.org/10.1016/j.chroma.2009.07.051[Crossref]
• [42] M. Ashraf-Khorassani, L.T. Taylor, E. Seest, J. Chromatogr. A 1226, 237 (2012)
• [43] K. Shikii, S. Sakamoto, H. Seki, H. Utsumi, K. Yamaguchi, Tetrahedron 60, 3487 (2004) http://dx.doi.org/10.1016/j.tet.2004.02.030[Crossref]
• [44] K. Chen, F. Lynen, M. De Beer, L. Hitzel, P. Ferguson, M. Hanna-Brown, P. Sandra, J. Chromatogr. A 1217, 7222 (2010) http://dx.doi.org/10.1016/j.chroma.2010.09.029[Crossref]
• [45] L. R. Snyder, Modern Practice of Liquid Chromatography (John Wiley and Sons Inc, New York, 1971)
• [46] S. Tsukahara, K. Saitoh, N. Suzuki, Chromatographia 51, 556 (2000) http://dx.doi.org/10.1007/BF02490812[Crossref]
• [47] H. Kim, K. Kaczmarski, G. Guiochon, J. Chromatogr. A 1101, 136 (2006) http://dx.doi.org/10.1016/j.chroma.2005.09.092[Crossref]
• [48] T. Cserháti, E. Forgács, J. Pharm. Biomed. Anal. 18, 497 (1998) http://dx.doi.org/10.1016/S0731-7085(98)00204-0[Crossref]
• [49] T. Komsta, R. Skibiński, A. Berecka, A. Gumieniczek, B. Radkiewicz, M. Radoń, J. Pharm. Biomed. Anal. 53, 911 (2010) http://dx.doi.org/10.1016/j.jpba.2010.06.024[Crossref]
• [50] E. H.M.A. Rabtti, M.M. Natić, D.M. Milojković-Opsenica, J.D. Trifković, I.M. Vuèković, V.E Vajs, Z.L. Tešić, J. Braz. Chem. Soc. 23, 522 (2012)

Identyfikatory

DOI

10.2478/s11532-013-0258-8