Five different columns in the analysis of basic drugs in hydrophilic interaction liquid chromatography

• Autorzy: Marko Jovanović , Biljana Stojanović , Tijana Rakić , Anđelija Malenović , Darko Ivanović , Mirjana Medenica
• Języki publikacji: EN

Abstrakty

EN

Five different columns (two silica, two cyanopropyl and one diol) were investigated in hydrophilic interaction liquid chromatography (HILIC). For the assessment of columns behavior in HILIC mode, six basic drugs (lamotrigine, thioridazine, clozapine, chlorpheniramine, pheniramine and sulpiride) were chosen. The assessment of the influence of the concentration of organic modifier on analytes’ retention on each column was provided by fitting the retention data into theoretical models. Utilizing the statistical analysis, the selection of the model that provides better prediction of the retention behavior was enabled. Dual RP-HILIC mechanism was suggested on cyanopropyl and diol columns, therefore the transition points between the two mechanisms on these columns were calculated. Furthermore, in order to investigate the impact of three factors simultaneously on the retention behavior of the analyzed substances on Betasil Silica column, chemometrically-aided empirical models were built. The experiments were conducted according to the matrix of Box-Behnken design and on the basis of the retention data, six quadratic models were obtained and their adequacy was confirmed using ANOVA test. The obtained coefficients of quadratic models enabled the elucidation of both single factor and factor interactions influence. This was also graphically presented in 3D response surface plots. [...]

Słowa kluczowe

EN

Hydrophilic interaction chromatography; Retention prediction; Retention behavior; Basic drugs; Box-Behnken design

• Czasopismo: Open Chemistry
• Rocznik: 2013
• Tom: 11
• Numer: 7
• Strony: 1150-1162

Daty

wydano

2013-07-01

online

2013-04-26

Twórcy

autor

Marko Jovanović

• Department of Drug Analysis, University of Belgrade — Faculty of Pharmacy, 11221, Belgrade, Serbia

autor

Biljana Stojanović

• Department of Drug Analysis, University of Belgrade — Faculty of Pharmacy, 11221, Belgrade, Serbia,

autor

Tijana Rakić

• Department of Drug Analysis, University of Belgrade — Faculty of Pharmacy, 11221, Belgrade, Serbia

autor

Anđelija Malenović

• Department of Drug Analysis, University of Belgrade — Faculty of Pharmacy, 11221, Belgrade, Serbia

autor

Darko Ivanović

• Department of Drug Analysis, University of Belgrade — Faculty of Pharmacy, 11221, Belgrade, Serbia

autor

Mirjana Medenica

• Department of Physical Chemistry and Instrumental Methods, University of Belgrade — Faculty of Pharmacy, 11221, Belgrade, Serbia

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Identyfikatory

DOI

10.2478/s11532-013-0245-0