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2013 | 11 | 6 | 927-934
Tytuł artykułu

A TLC Study of the lipophilicity of thirty-two acetylcholinesterase inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The lipophilicity of thirty-two novel acetylcholinesterase (AChE) inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives was studied by thin layer chromatography. The analyzed compounds were chromatographed on RP-18, RP-8, RP-2, CN and NH2 stationary phases with dioxane - citric buffer pH 3.0 binary mobile phases containing different proportions of dioxane. RM values for pure water were extrapolated from the linear Soczewiński-Wachtmeister equation and six compounds with known literature log P values were used as reference calibration data set for computation of experimental log P values. [...] The obtained results were compared with computationally calculated partition coefficients values (AlogPs, AClogP, AlogP, MlogP, KOWWIN, XlogP2, XlogP3) by PCA and significant differences between them were observed.
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
6
Strony
927-934
Opis fizyczny
Daty
wydano
2013-06-01
online
2013-03-28
Twórcy
  • Department of Pharmaceutical Chemistry and Drug Analyses, Medical University, 90-151, Łódź, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland
  • Department of Pharmaceutical Chemistry and Drug Analyses, Medical University, 90-151, Łódź, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland, lukasz.komsta@umlub.pl
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0218-3
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