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2013 | 11 | 5 | 706-716
Tytuł artykułu

Voltammetric methods of reboxetine analysis and the mechanism of its electrode reactions

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Reboxetine (RBX) electrochemical redox behavior at hanging mercury drop (HMDE) and glassy carbon electrodes (GCE) was studied in various pH Britton-Robinson universal buffers using cyclic voltammetry and square-wave voltammetry. RBX was reduced at the HMDE and oxidized at the GCE with reversible adsorption controlled and irreversible diffusion controlled processes respectively. The anodic peak is due to the amine and the cathodic peak may correspond to oxygen protonation. An oxidation reaction mechanism is proposed. The linear relation between peak currents and RBX concentration allowed simple, sensitive, precise and inexpensive voltammetric procedures to be developed. The limit of detection was 0.04 µM RBX. The procedures were successfully applied to human urine and RBX tablet assay. Therapeutic RBX concentrations in human serum were not detected due to strong drug-protein binding. Using bovine serum albumin, the methods were used to investigate the effect of serum protein binding on RBX determination. [...]
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Wydawca

Czasopismo
Rocznik
Tom
11
Numer
5
Strony
706-716
Opis fizyczny
Daty
wydano
2013-05-01
online
2013-02-27
Twórcy
  • Department of Chemistry, Faculty of Science, Ankara University, 06100, Ankara, Turkey, erdodeniz@gmail.com
autor
  • Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, 06100, Ankara, Turkey
  • Department of Chemistry, Faculty of Science, Ankara University, 06100, Ankara, Turkey
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0213-8
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