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Czasopismo
2013 | 11 | 3 | 430-437
Tytuł artykułu

First synthesis of important secondary oxidative metabolites of morphine and codeine with the Michael addition

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Abstract Morphine (1) and codeine (2) are two representatives of medically important, frequently used natural opiates, therefore the exploration of their metabolic pathways and the exact characterization of the metabolites are main targets of their pharmacological studies. These morphinans also play a crucial role in drug abuse; therefore, the analysis and preparation of the metabolites for identification and quantitation in human samples are considered important aims. In order to allow the in-depth analysis of metabolites derived from the oxidative pathways through morphinone (3) and codeinone (4), synthetic procedures have been elaborated for the gram-scale preparation of glutathione and N-acetylcysteine adducts. Primary pharmacological studies revealed the inactive nature of these metabolites in opioid receptor binding tests. Graphical abstract [...]
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
3
Strony
430-437
Opis fizyczny
Daty
wydano
2013-03-01
online
2012-12-28
Twórcy
  • Department of Organic Chemistry, University of Debrecen, H-4032, Debrecen, Hungary
  • Department of Organic Chemistry, University of Debrecen, H-4032, Debrecen, Hungary
  • Department of Organic Chemistry, University of Debrecen, H-4032, Debrecen, Hungary
autor
  • Department of Pharmaceutical Chemistry, Medical and Health Science Center, University of Debrecen, H-4032, Debrecen, Hungary, sipos.attila@pharm.unideb.hu
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0181-4
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