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2013 | 11 | 2 | 137-139
Tytuł artykułu

Susceptibility to hydrolysis of phenylboronic pinacol esters at physiological pH

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Boronic acids and their esters are highly considered compounds for the design of new drugs and drug delivery devices, particularly as boron-carriers suitable for neutron capture therapy. However, these compounds are only marginally stable in water. Hydrolysis of some phenylboronic pinacol esters is described here. The kinetics is dependent on the substituents in the aromatic ring. Also the pH strongly influences the rate of the reaction, which is considerably accelerated at physiological pH. Therefore, care must be taken when considering these boronic pinacol esters for pharmacological purposes. [...]
Wydawca

Czasopismo
Rocznik
Tom
11
Numer
2
Strony
137-139
Opis fizyczny
Daty
wydano
2013-02-01
online
2012-11-29
Twórcy
  • Laboratories of Biochemistry, Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, 21-27100, Pavia, Italy
  • Laboratories of Biochemistry, Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, 21-27100, Pavia, Italy
  • Department of Chemistry, University of Pavia, 12-27100, Pavia, Italy
  • Laboratories of Biochemistry, Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, 21-27100, Pavia, Italy
  • Laboratories of Biochemistry, Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, 21-27100, Pavia, Italy, minetti@unipv.it
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0159-2
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