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2013 | 11 | 2 | 290-294
Tytuł artykułu

Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin. [...]
Wydawca
Czasopismo
Rocznik
Tom
11
Numer
2
Strony
290-294
Opis fizyczny
Daty
wydano
2013-02-01
online
2012-11-29
Twórcy
  • Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil
  • Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil
  • Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil
  • Chemistry Department, Federal University of Minas Gerais, Campus Pampulha, 31, 270-901, Belo Horizonte — MG, Brazil
  • Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil
  • Chemistry Department, Federal University of Minas Gerais, Campus Pampulha, 31, 270-901, Belo Horizonte — MG, Brazil
  • Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil , wg@iqufu.ufu.br
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0156-5
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