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2012 | 10 | 6 | 1842-1849
Tytuł artykułu

A simple and precise conductometric method for the determination of losartan in pharmaceutical products

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Losartan is an antihypertensive agent that lost its patent protection in 2010, and, consequently, it has been available in generic form. The latter motivated the search for a rapid and precise alternative method. Here, a simple conductometric titration in aqueous medium is described for the losartan analysis in pharmaceutical formulations. The first step of the titration occurs with the protonation of losartan producing a white precipitate and resulting in a slow increase in conductivity. When the protonation stage is complete, a sharp increase in conductivity occurs which was determined to be due to the presence of excess of acid. The titrimetric method was applied to the determination of losartan in pharmaceutical products and the results are comparable with values obtained using a chromatographic method recommended by the United States Pharmacopoeia. The relative standard deviation for successive measurements of a 125 mg L−1 (2.71×10−4 mol L−1) losartan solution was approximately 2%. Recovery study in tablet samples ranged between 99 and 102.4%. The procedure is fast, simple, and represents an attractive alternative for losartan quantification in routine analysis. In addition, it avoids organic solvents, minimizes the risk of exposure to the operator, and the waste treatment is easier compared to classical chromatographic methods. [...]
Wydawca
Czasopismo
Rocznik
Tom
10
Numer
6
Strony
1842-1849
Opis fizyczny
Daty
wydano
2012-12-01
online
2012-09-21
Twórcy
  • Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil
  • Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil
  • Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil , luangnes@iq.usp.br
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0110-6
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