Spatial relationships between the pharmacophores of endomorphin-2: a comparative study of stereoisomers

• Autorzy: Balázs Leitgeb
• Języki publikacji: EN

Abstrakty

EN

The spatial relationships between the pharmacophore elements were investigated in the case of four different stereoisomeric forms of opioid tetrapeptide, endomorphin-2, taking into account the L-D and cis-trans isomerisms. On the basis of distances and angles measured between the pharmacophoric points, a comparative analysis of conformational distributions was performed, applying a variety of distance-angle maps. The results obtained by this theoretical study indicated that the stereoisomers of endomorphin-2 could be distinguished from one another, based on the comparative analysis of distance-angle maps. Nevertheless, it could be concluded that this method proved to be suitable to examine the effects of L-D and cis-trans isomerisms on the spatial relationships of the pharmacophores of tetrapeptide. [...]

Słowa kluczowe

EN

Endomorphin; Pharmacophore; Conformational analysis; L-D isomerism; Cis-trans isomerism

• Czasopismo: Open Chemistry
• Rocznik: 2012
• Tom: 10
• Numer: 6
• Strony: 1791-1798

Daty

wydano

2012-12-01

online

2012-09-21

Twórcy

autor

Balázs Leitgeb

• Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, H-6726, Szeged, Hungary,

Bibliografia

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Identyfikatory

DOI

10.2478/s11532-012-0105-3