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2012 | 10 | 6 | 1791-1798
Tytuł artykułu

Spatial relationships between the pharmacophores of endomorphin-2: a comparative study of stereoisomers

Autorzy
Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The spatial relationships between the pharmacophore elements were investigated in the case of four different stereoisomeric forms of opioid tetrapeptide, endomorphin-2, taking into account the L-D and cis-trans isomerisms. On the basis of distances and angles measured between the pharmacophoric points, a comparative analysis of conformational distributions was performed, applying a variety of distance-angle maps. The results obtained by this theoretical study indicated that the stereoisomers of endomorphin-2 could be distinguished from one another, based on the comparative analysis of distance-angle maps. Nevertheless, it could be concluded that this method proved to be suitable to examine the effects of L-D and cis-trans isomerisms on the spatial relationships of the pharmacophores of tetrapeptide. [...]
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
6
Strony
1791-1798
Opis fizyczny
Daty
wydano
2012-12-01
online
2012-09-21
Twórcy
  • Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, H-6726, Szeged, Hungary, leitgeb@brc.hu
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0105-3
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