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Czasopismo
2012 | 10 | 4 | 1360-1368
Tytuł artykułu

Use of an immiscible diluent in ionic liquid / ion pair LC for the assay of an injectable analgesic

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Injectable solutions used in treatment of intense pain are based on combinations of active ingredients such as metamizole sodium (MTZ), pitofenone hydrochloride (PTF) and fenpiverine bromide (FPB). The simultaneous chromatographic assay of such combinations poses difficulties due to their structural variety, highly polar character, and wide concentration ranges (500 mg mL−1 for MTZ, 2 mg mL−1 for PTF and 0.02 mg mL−1 for FPB). Fast hydrolysis of MTZ on aqueous dilution causes additional problems due to impurity (MTC) formation. Sodium hexane sulphonate (10 mM) was used as ion pairing agent for PTF, FPB and MTC in a mobile phase consisting of 48/52 (v/v) methanol and aqueous 0.2% triethylamine at pH=3. The ionic liquid 1-butyl-1-methyl-pyrrolidinium tetrafluoroborate (10 mM) was used as mobile phase additive to preserve the MTZ peak symmetry. The minor active ingredient FPB was selectively extracted into 1-octanol by ion pair formation with picric acid. A 20 µL aliquot of the organic layer was directly injected into the column. [...]
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
4
Strony
1360-1368
Opis fizyczny
Daty
wydano
2012-08-01
online
2012-05-29
Twórcy
autor
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
autor
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania, avmedved@yahoo.com
Bibliografia
  • [1] A. Berthod, M. Ruiz-Angel, S. Carda-Broch, J. Chromatogr. A 1184, 6 (2008) http://dx.doi.org/10.1016/j.chroma.2007.11.109[Crossref]
  • [2] D. Han, K.H. Row, Molecules 15, 2405 (2010) http://dx.doi.org/10.3390/molecules15042405[Crossref]
  • [3] L.H. Marcolino-Junior, R.A. Sousa, O. Fatibello-Filho, F.C. Moraes, M. Teixeira, Anal. Lett. 14, 2315 (2005) http://dx.doi.org/10.1080/15265160500316351[Crossref]
  • [4] Q. Xiang, G. Niu, X. Wu, G. Chen, Chem. Res. Chin. Univ. 6, 654 (2007) http://dx.doi.org/10.1016/S1005-9040(07)60142-1[Crossref]
  • [5] N. Erk, F. Onur, Anal. Lett. 30, 1201 (1997) http://dx.doi.org/10.1080/00032719708004049[Crossref]
  • [6] H.N. Dogan, Pharmazie 51, 773 (1996)
  • [7] T. Aburjai, B.I. Amro, K. Aiedeh, M. Abuirjeie, S. Al-Khalil, Pharmazie 55, 751 (2000)
  • [8] B. Morelli, Anal. Lett. 31, 2431 (1998) http://dx.doi.org/10.1080/00032719808005316[Crossref]
  • [9] Y. Huang, C. Zhang, X. Zhang, Z. Zhang, Anal. Lett. 32, 933 (1999) http://dx.doi.org/10.1080/00032719908542867[Crossref]
  • [10] H.Z. Senyuva, I. Aksahin, S. Ozcan, B.V. Kabasakal, Anal. Chim. Acta 547, 73 (2005) http://dx.doi.org/10.1016/j.aca.2004.12.053[Crossref]
  • [11] A. Salmeron-Garcia, N. Navas, A. Martin, E. Roman, J. Cabeza, L.F. Capitan-Vallvey, J. Chrom. Sci. 3, 231 (2009) [Crossref]
  • [12] L.G. Tillman, G.E. Hardee, Anal. Lett. 15, 1897 (1985) http://dx.doi.org/10.1080/00032718508062915[Crossref]
  • [13] B. Morelli, J. Pharm. Biomed. Anal. 3, 423 (2003) http://dx.doi.org/10.1016/S0731-7085(03)00290-5[Crossref]
  • [14] V. Kubicek, D. Kucova, P. Cisar, V. Buresova, Microchim. Acta 142, 273 (2003) http://dx.doi.org/10.1007/s00604-003-0031-3[Crossref]
  • [15] D. Radulovic, L. Zivarovic, D. Zivanov-Stakic, Acta Pol. Pharm. 46, 506 (1989)
  • [16] ChemAxon Software: Marvin with calculator plugins, version 5.4.0.0 (ChemAxon, Hungary, 2010)
  • [17] M.P. Marszall, R. Kaliszan, Critical Rev. Anal. Chem. 37, 127 (2007) http://dx.doi.org/10.1080/10408340601107847[Crossref]
  • [18] Y. Wang, M. Tian, W. Bi, K.H. Row, Int. J. Mol. Sci. 10, 2591 (2009) http://dx.doi.org/10.3390/ijms10062591[Crossref]
  • [19] L. He, W. Zhang, L. Zhao, X. Liu, S. Jiang, J. Chromatogr. A 1007, 39 (2003) http://dx.doi.org/10.1016/S0021-9673(03)00987-7[Crossref]
  • [20] S. Udrescu, A. Medvedovici, V. David, J. Sep. Sci. 31, 2939 (2008) http://dx.doi.org/10.1002/jssc.200800299[Crossref]
  • [21] A. Medvedovici, V. David, V. David, C. Georgita, J. Liq. Chrom. & Rel. Technol. 30, 199 (2007) http://dx.doi.org/10.1080/10826070601064201[Crossref]
  • [22] S. Udrescu, I. Sora, F. Albu, V. David, A. Medvedovici, J. Pharm. Biomed. Anal. 54, 1163 (2011) http://dx.doi.org/10.1016/j.jpba.2010.12.005[Crossref]
  • [23] A. Medvedovici, S. Udrescu, F. Albu, F. Tache, V. David, Bioanalysis 3, 1935 (2011) http://dx.doi.org/10.4155/bio.11.148[Crossref]
  • [24] S. Keunchkarian, M. Reta, L. Romero, C. Castells, J. Chromatogr. A 1119, 20 (2006) http://dx.doi.org/10.1016/j.chroma.2006.02.006[Crossref]
  • [25] E. Loeser, P. Drumm, J. Sep. Sci. 29, 2487 (2006) http://dx.doi.org/10.1002/jssc.200600299[Crossref]
  • [26] E. Loeser, S. Babiak, P. Drumm, J. Chromatogr. A 1216, 3409 (2009) http://dx.doi.org/10.1016/j.chroma.2009.02.012[Crossref]
  • [27] Q2B Validation of Analytical Procedures: Methodology (Center for Drug Evaluation and Research, ICH, 1996)
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0059-5
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