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2012 | 10 | 4 | 1253-1261
Tytuł artykułu

The interaction of [Pd(N,N-dimethylaminopropylamine)(H2O)]2+ with dicarboxylic acids and inosine: Thermodynamic model for carboplatin drug

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The Pd(DMPA)Cl2 complex, where DMPA = N,N-dimethylaminoproylamine, was synthesized and characterized. The stoichiometry and stability constants of the complexes formed between various dicarboxylic acids and [Pd(DMPA)(H2O)2]2+ were investigated. The effect of solvent dielectric constant, chloride ion concentration of the medium and temperature on the stability constant of the cyclobutanedicaroxylic acid (CBDCA) complex was investigated. The equilibrium constants for the displacement of coordinated CBDCA by inosine, taken as an example of DNA constituents, were calculated. The results are expected to contribute to the chemistry of antitumour agents. [...]
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
4
Strony
1253-1261
Opis fizyczny
Daty
wydano
2012-08-01
online
2012-05-29
Twórcy
  • Department of Chemistry, Faculty of Science, University of Cairo, 12613, Giza, Egypt
  • Department of Chemistry, Faculty of Science, University of Cairo, 12613, Giza, Egypt, shoukrymm@hotmail.com
autor
  • Department of Chemistry, Faculty of Science, University of Cairo, 12613, Giza, Egypt
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0053-y
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