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Czasopismo
2012 | 10 | 4 | 1034-1041
Tytuł artykułu

Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Novel heavy metal complexes: Sr(5-NH2-phen)4(NO3)(OH)(H2O)2 (1) (synthesized via a static self-assembly process) and Sn(phen)(NO3)(OH)(H2O) (2), Sn(5-NH2-phen)(OH)(Cl)(H2O) (3), Pb(5-NH2-phen)(NO3)2(H2O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured by MTS-test towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The most pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high concentrations as well as 1 at its lower ones (≤ 4×10−2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities ≤ 4×10−2 mg. The computed EC50 values of 1–4 against MDA-MB-231, HT-29, HeLa, HepG2 varied from 1.40×10−3 to 6.31×10−6 M. Towards Lep-3 substances 2–4 showed IC50 7.52×10−4 − 0.44 M. Substance 1 possess EC50=1.26×10−7 M to the non-tumour cells. [...]
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
4
Strony
1034-1041
Opis fizyczny
Daty
wydano
2012-08-01
online
2012-05-29
Twórcy
  • Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, 1756, Bulgaria, nikolaykaloyanov@yahoo.com
  • Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, 1756, Bulgaria
  • Institute of Experimental Morphology, Pathology and Anthropology with Muzeum, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria
  • Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, 1756, Bulgaria
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0046-x
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