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2012 | 10 | 3 | 686-702
Tytuł artykułu

Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions: Current status and perspectives

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Over the last years, interest in intranasal administration as an alternative and promising route for the delivery of drugs withlocal, systemic, and even central nervous system action has tremendously increased. Accordingly, understanding of the propertiesand characteristics of the nasal cavity as well as the biodisposition processes of drugs into the nasal compartments is acquiringa significant prominence in the field of pharmacology. In this context, the development and validation of bioanalytical methodologies for the quantitative measurement of drugs and their metabolites in nasal and paranasal tissues and/or secretions is of the utmostimportance. However, currently, information concerning bioanalysis of drugs in nasal and paranasal tissues and/or secretionsis scattered. This review aims to provide a valuable overview of the methodologies that have been used for the collectionand preparation of nasal and paranasal samples with special emphasis placed on the review of liquid chromatographic methodsemployed for the quantitative determination of small-molecule drugs and their metabolites in such specimens. [...]
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
3
Strony
686-702
Opis fizyczny
Daty
wydano
2012-06-01
online
2012-03-23
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0021-6
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