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Czasopismo
2012 | 10 | 1 | 216-223
Tytuł artykułu

Determination of lipophilicity for antitumor acridinone derivatives supported by gradient high-performance liquid chromatography method

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The lipophilicity values of selected acridinone (imidazoacridinone and triazoloacridinone) derivatives were measured by gradient reversed-phase high-performance liquid chromatography (RP-HPLC) using a C18 stationary phase with a water/acetonitrile mixture as a mobile phase. The retention times obtained served as input data and appropriate log kw values (i.e., the retention factor log kw extrapolated to 0% organic modifier) as an alternative to log P were calculated using the DryLab program. The relationships between the lipophilicity (log kw) and the chemical structure of the studied compounds, as well as correlation between experimentally determined lipophilicities (log kw) and log P data calculated using some commonly available software, are discussed.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Strony
216-223
Opis fizyczny
Daty
wydano
2012-02-01
online
2011-11-24
Twórcy
autor
  • Collegium Medicum of Nicolaus Copernicus University
  • Medical University of Gdańsk
  • Norwegian University of Science and Technology
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-011-0131-6
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