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2011 | 9 | 6 | 1117-1125
Tytuł artykułu

Amphiphilic azopolymers capable to generate photo-sensitive micelles

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Amphiphilic macromolecular micelles are advantageous for drug delivery applications due to the decrease of side-effects, ease of screening drugs against degradation, long-term stability, targeted delivery and control of the amount of the released drug. A series of amphiphilic azo-polymers having a flexible or rigid main-chain were synthesized and characterized. The presence of chlorobenzyl side-groups allowed both the easy bonding of photo-sensitive or hydrophilic groups and good control of the degree of substitution. The chemical structure was confirmed by 1H-NMR. The critical concentration of aggregation (CCA) was calculated using the fluorescence emission spectrum of pyrene. The interest was focused on a preliminary study concerning the disaggregation capacity of micelles under UV irradiation. The presence of micellar aggregates was confirmed by DLS and SEM and different organization of the amphiphilic polymers was evidenced depending on polymers concentration and polymers structure. In low polymer concentrations in water predominantly globular aggregates were formed. The increase in concentration increased the polydispersity index due to the fusion of micelles and formation of associates of globular aggregates, inter-micellar associates (clusters) and vesicles. [...]
Wydawca

Czasopismo
Rocznik
Tom
9
Numer
6
Strony
1117-1125
Opis fizyczny
Daty
wydano
2011-12-01
online
2011-09-27
Twórcy
  • Department of Natural and Synthetic Polymers, «Gheorghe Asachi» Technical University of Iasi, 700050, Iasi, Romania
  • Department of Natural and Synthetic Polymers, «Gheorghe Asachi» Technical University of Iasi, 700050, Iasi, Romania
  • Department of Natural and Synthetic Polymers, «Gheorghe Asachi» Technical University of Iasi, 700050, Iasi, Romania
  • Department of Physical Chemistry of Polymers, «Petru Poni» Institute of Macromolecular Chemistry, 700487, Iasi, Romania
  • Department of Natural and Synthetic Polymers, «Gheorghe Asachi» Technical University of Iasi, 700050, Iasi, Romania, nhurduc@ch.tuiasi.ro
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-011-0102-y
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