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2011 | 9 | 4 | 635-647
Tytuł artykułu

Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial drugs against most of employed strains, as evident from the screening data. [...]
Wydawca

Czasopismo
Rocznik
Tom
9
Numer
4
Strony
635-647
Opis fizyczny
Daty
wydano
2011-08-01
online
2011-06-04
Twórcy
  • Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India
  • Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India
autor
  • Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India
autor
  • Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India, patelranjanben@yahoo.com
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-011-0041-7
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