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Czasopismo
2011 | 9 | 1 | 143-148
Tytuł artykułu

Use of pyridinium ionic liquids as catalysts for the synthesis of 3,5-bis(dodecyloxycarbonyl)-1,4-dihydropyridine derivative

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The synthesis of cationic amphiphilic 1,4-dihydropyridine derivative, potential gene delivery agent is achieved via an efficient multi-step sequence. The key step of this approach is a two-component Hantzsch type cyclisation of 3-oxo-2-[1-phenylmethylidene]-butyric acid dodecyl ester and 3-amino-but-2-enoic acid dodecyl ester utilising bis(2-hydroxyethyl)ether as a solvent and 1-butyl-4-methylpyridinium chloride as a catalyst. The 1,4-dihydropyridine derivative with long alkyl ester chains at positions 3 and 5 of the 1,4-DHP ring - 3,5-bis(dodecyloxycarbonyl)-2,6-dimethyl-4-phenyl-1,4-dihydropyridine was obtained in substantially higher yield with respect to classical Hantzsch synthesis. Bromination of this compound followed by nucleophilic substitution of bromine with pyridine gave the desired cationic amphiphilic 1,4-dihydropyridine. [...]
Wydawca

Czasopismo
Rocznik
Tom
9
Numer
1
Strony
143-148
Opis fizyczny
Daty
wydano
2011-02-01
online
2010-12-16
Twórcy
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia
autor
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia
  • Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia, arkady@osi.lv
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0132-x
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