Stability-indicating derivative spectrophotometry method for the determination of biapenem in the presence of its degradation products

• Autorzy: Judyta Cielecka-Piontek , Aran Lunzer , Anna Jelińska
• Języki publikacji: EN

Abstrakty

EN

A first-derivative UV spectrophotometric method, with or without the subtraction technique, was developed for the determination of biapenem in pharmaceutical dosage form in the presence of its degradation products. The method was based on the measurement of first-derivative amplitudes at zero crossing point (λ = 312 nm) and the peak-to-zero technique and validated with regard to linearity, limits of detection and quantitation, selectivity and precision. The observed rate constants for the degradation of biapenem were comparable to those obtained in the stability-indicating HPLC method. [...]

Słowa kluczowe

EN

Biapenem; Degradation; First-derivative UV

• Czasopismo: Open Chemistry
• Rocznik: 2011
• Tom: 9
• Numer: 1
• Strony: 35-40

Daty

wydano

2011-02-01

online

2010-12-16

Twórcy

autor

Judyta Cielecka-Piontek

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-780, Poznań, Poland,

autor

Aran Lunzer

• Tanaka Laboratory in Hokkaido University, W7, Kita-ku, Sapporo, 060-8638, Japan

autor

Anna Jelińska

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-780, Poznań, Poland

Bibliografia

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Identyfikatory

DOI

10.2478/s11532-010-0125-9