PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Czasopismo
2010 | 8 | 4 | 744-749
Tytuł artykułu

The protection of Nifedipin from photodegradation due to complex formation with β-cyclodextrin

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The inclusion complex β-cyclodextrin:nifedipin was prepared in solid state by coprecipitation with 1:1 mol ratio. The structure of the obtained complex and nifedipin was characterized by use of X-ray diffraction (XR), infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and differential scanning calorimetry (DSC) methods. The photodegradation of nifedipin and the β-cyclodextrin:nifedipin inclusion complex in solid state was monitored under natural daylight by infrared spectroscopy, whereby the free nifedipin degraded four to five times faster than the complexed nifedipin. The photodegradation products of both free and complexed nifedipin, formed during irradiation at 350 nm (with corresponding energy flux of 18 W m−2) were monitored by liquid chromatography during various time intervals. The speed of formation of nitroso- and nitro-phenyl derivatives by nifedipin irradiation was significantly higher than those of complexed nifedipin irradiation, which indicates its increased photostability in the inclusion complex. The effect on this property is significant because it contributes both to the improvement of the therapeutic effect of nifedipin and to the safer application thereof. [...]
Wydawca

Czasopismo
Rocznik
Tom
8
Numer
4
Strony
744-749
Opis fizyczny
Daty
wydano
2010-08-01
online
2010-06-17
Twórcy
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia, nvesna@yahoo.com
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
autor
  • Faculty of Sciences, Department of Physics, University of Novi Sad, 21000, Novi Sad, Serbia
  • Faculty of Sciences, Department of Chemistry, University of Novi Sad, 21000, Novi Sad, Serbia
Bibliografia
  • [1] M. Shamsipur, B. Hemmateenejad, M. Akhond, K. Javidnia, R. Miri, J. Pharm. Biomed. Anal. 31, 1013 (2003) http://dx.doi.org/10.1016/S0731-7085(02)00710-0[Crossref]
  • [2] M.A. Bayomi, K.A. Abanumay, A.A. Al-Angary, Int. J. Pharm. 243, 107 (2002) http://dx.doi.org/10.1016/S0378-5173(02)00263-6[Crossref]
  • [3] D.L. Savigni, D. Wege, G.S. Cliff, M.L.H. Meesters, E.H. Morgan, Biochem. Pharmacol. 65, 1215 (2003) http://dx.doi.org/10.1016/S0006-2952(03)00045-5[Crossref]
  • [4] V.B. Patravale, V.B. Nair, S.P. Gore, J. Pharm. Biomed. Anal. 23, 623 (2000) http://dx.doi.org/10.1016/S0731-7085(00)00317-4[Crossref]
  • [5] R. Teraoka, M. Otsuka, Y. Matsuda, Int. J. Pharm. 184, 35 (1999) http://dx.doi.org/10.1016/S0378-5173(99)00089-7[Crossref]
  • [6] I.A. Majeed, W.J. Murray, D.W. Newton, S. Othman, W.A. Alturk, J. Pharm. Pharmacol. 39, 1044 (1987) [Crossref]
  • [7] Y. Mastuda, R. Teraoka, I. Sugimoto, Int. J. Pharm. 54, 211 (1989) http://dx.doi.org/10.1016/0378-5173(89)90098-7[Crossref]
  • [8] I. Matsuura, M. Imaizumi, M. Sugiyama, Chem. Pharm. Bull. 38, 1692 (1990) [Crossref]
  • [9] N. Škalko, M. Brandl, M. BeĆireviĆ-Laćan, J. Filipović-GrčiĆ, I. Jalšenjak, Eur. J. Pharm. Sci. 4, 359 (1996) http://dx.doi.org/10.1016/S0928-0987(96)00180-7[Crossref]
  • [10] J. Mielcarek, Pharmazie 51, 477 (1996)
  • [11] K.L. Andrew Chan, S.G. Kazarian, Mol. Pharm. 1, 331 (2004) http://dx.doi.org/10.1021/mp049973m[Crossref]
  • [12] J. Szejtli, Chem. Rev. 98, 1743 (1998) http://dx.doi.org/10.1021/cr970022c[Crossref]
  • [13] P. Giastas, K. Yannakopoulou, I.M. Mavridis, Acta Cryst. B59, 287 (2003)
  • [14] M.M. Pop et al., Acta Cryst. B58, 1036 (2002)
  • [15] H.J. Schneider, F. Hacket, V. Rodiger, Chem. Rev. 98, 1755 (1998) http://dx.doi.org/10.1021/cr970019t[Crossref]
  • [16] V.T. D’souza, K.B. Lipkowitz, Chem. Rev. 98, 1749 (1998)
  • [17] T. Loftsson, J. Buldvinsdottr, A.M. Sigurdardottir, Int. J. Pharm. 98, 225 (1993) http://dx.doi.org/10.1016/0378-5173(93)90060-S[Crossref]
  • [18] R.A. Rajewski, V.J. Stella, J. Pharm. Sci. 85, 1142 (1996) http://dx.doi.org/10.1021/js960075u[Crossref]
  • [19] V. Nikolić, M. Stanković, A. Kapor, Lj. Nikolić, D. Cvetković, J. Stamenković, Pharmazie 59, 845 (2004)
  • [20] V. Nikolić, Lj. Nikolić, M. Stanković, A. Kapor, M. Popsavin, D. Cvetković, J. Serb. Chem. Soc. 72, 737 (2007) http://dx.doi.org/10.2298/JSC0709737N[Crossref]
  • [21] R. Ficarra et al., J. Pharm. Biomed. Anal. 23, 33 (2000) http://dx.doi.org/10.1016/S0731-7085(00)00261-2[Crossref]
  • [22] R. Ficarra et al. J. Pharm. Biomed. Anal. 23, 232 (2000)
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0043-x
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.