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2010 | 8 | 3 | 687-695
Tytuł artykułu

Synthesis and characterization of molecularly imprinted polymer for controlled release of tramadol

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In this paper, we describe how to prepare a highly selective imprinted polymer by a bulk polymerization technique. We used tramadol as the template, (MAA) as functional monomers, and (EGDMA) as the cross-linker in chloroform as solvent. Results from Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Scanning Electron microscopy (SEM) show that this imprinted sorbent exhibits good recognition and high affinity for tramadol. Selectivity of molecularly imprinted polympers (MIP) was evaluated by comparing several substances with similar molecular structures to that of tramadol. Controlled release of tramadol from MIPs was investigated through in vitro dissolution tests and by measuring the absorbance at λmax of 272 nm by (HPLC-UV). The dissolution media employed were hydrochloric acid pH 3.0 and phosphate buffers, pH 5.0 and 7.4, maintained at 37 and 25 ± 0.5°C. The results show the ability of MIP polymers to control tramadol release. In all cases, the release of MIPs was deferred for a longer time as compared to NMIP. At a pH of 7.4 and 25°C slower release of tramadol imprinted polymer occurred. [...]
Wydawca

Czasopismo
Rocznik
Tom
8
Numer
3
Strony
687-695
Opis fizyczny
Daty
wydano
2010-06-01
online
2010-04-25
Twórcy
  • Department of Chemistry, Amirkabir University of Technology, Hafez 424, Tehran, P.O. Box 15875-4413, Iran
  • Department of Chemistry, Amirkabir University of Technology, Hafez 424, Tehran, P.O. Box 15875-4413, Iran, majidabdouss@yahoo.com
  • Department of Chemistry, College of Science, Semnan University, Semnan, Iran
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0035-x
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