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2010 | 8 | 3 | 550-558
Tytuł artykułu

Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis. The crystal structure of 1a was determined from single crystal X-ray diffraction data. It crystallizes in monoclinic space group P21/n with unit cell dimensions a = 11.7752(6) Å, b= 3.8677(2) Å, c= 27.4126(13) Å and β = 92.734(5) Å. There is a strong intramolecular hydrogen bond of the type N-H⋯O, with H⋯O distance of 2.5869(19) Å. The mass fragmentation pattern has also been discussed. The antifungal activity of the synthesized compounds was studied by broth micro-dilution method and poisoned food technique. The compounds 1b and 1c possessed a broad spectrum of antifungal activity. [...]
Wydawca

Czasopismo
Rocznik
Tom
8
Numer
3
Strony
550-558
Opis fizyczny
Daty
wydano
2010-06-01
online
2010-04-25
Twórcy
autor
  • Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, Pakistan
  • Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, Pakistan
autor
  • Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Postfach 3329, 38023, Braunschweig, Germany
  • National Engineering & Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
  • Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, Pakistan
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0014-2
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