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2010 | 8 | 1 | 163-173
Tytuł artykułu

Rapid synthesis and biological evaluation of 1,4-dihydropyridine derivatives containing a benzothiazolyl moiety

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines were synthesized by reaction of 2-amino-6-methylbenzothiazole, aromatic aldehyde and active methylene compound in methanol by conventional, as well as, microwave irradiation (solvent free and solid support) methods. The microwave irradiation technique gives better yield and shorter reaction time. Among solid supported microwave irradiation better yields are obtained in acidic alumina as compared to silica, neutral alumina, and basic alumina. All compounds were tested for antibacterial and antifungal activities and results have been compared with standard drugs. Entomological activities were also tested. The results showed that a change in the substitution pattern in 1,4-dihydropyridine derivatives may cause a marked effect on their antimicrobial activity. [...]
Wydawca

Czasopismo
Rocznik
Tom
8
Numer
1
Strony
163-173
Opis fizyczny
Daty
wydano
2010-02-01
online
2010-02-16
Twórcy
autor
  • Department of Pure and Applied Chemistry, M.D.S. University, Ajmer, 305009, India
autor
  • Department of Pure and Applied Chemistry, M.D.S. University, Ajmer, 305009, India
autor
  • Hygia Institute of Pharmaceutical Education and Research, Lucknow, 226020, India
  • SAIF Division, Central Drug Research Institute, Lucknow, 226020, India
autor
  • Department of Pure and Applied Chemistry, M.D.S. University, Ajmer, 305009, India, kgojha@rediffmail.com
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-009-0114-z
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