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2009 | 7 | 2 | 246-251
Tytuł artykułu

Potential applications of fluorhydroxyapatite as biomaterials in medicine

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The present work was undertaken to investigate the bioactivity and cytotoxicity of fluorhydroxyapatite ceramics. The bioactivity was evaluated by in vitro testing in simulated body fluid (SBF), in which ion concentrations are almost identical with inorganic ion concentrations of human blood plasma. Pellets of FA, HA and FHA were immersed in SBF for 48 hours, 1 week and 4 weeks at 36.5°C. Changes of the surface microstructure of the samples were observed by scanning electron microscopy (SEM). 48 hours and one week immersion in SBF did not result in any substantial progress in bioactivity. After 4 weeks in SBF a new biologically active layer was created on the surface of the biomaterials. In addition, the embryonal mouse fibroblast cell line NIH-3T3 was used for a comparative study of basal cytotoxicity of FHA, HA and FA discs. The sensitivity of these cells for tested biomaterials was evaluated on the basis of two cytotoxic end points: cell proliferation and cell morphology. The basal cytotoxicity of FHA, FA and HA discs was measured by a direct contact method. After 24, 48 and 72 hours, the cell growth was evaluated by direct counting of non-affected cells and cells treated by biomaterials. After 72 hours of biomaterials treatment, about 25% inhibition of cell number and unchanged morphology was found. [...]
Wydawca

Czasopismo
Rocznik
Tom
7
Numer
2
Strony
246-251
Opis fizyczny
Daty
wydano
2009-06-01
online
2009-04-09
Twórcy
  • Slovak University of Technology, Faculty of Chemical and Food Technology, 812 37, Bratislava, Slovak Republic, martin.vitkovic@stuba.sk
autor
  • Slovak University of Technology, Faculty of Chemical and Food Technology, 812 37, Bratislava, Slovak Republic
autor
  • Slovak University of Technology, Faculty of Chemical and Food Technology, 812 37, Bratislava, Slovak Republic
  • Slovak University of Technology, Faculty of Chemical and Food Technology, 812 37, Bratislava, Slovak Republic
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-009-0010-6
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