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2008 | 6 | 2 | 267-276
Tytuł artykułu

QSAR modeling for lipid peroxidation inhibition potential of flavonoids using topological and structural parameters

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In the present study, Quantitative Structure-Activity Relationship (QSAR) modeling has been carried out for lipid peroxidation (LPO)-inhibition potential of a set of 27 flavonoids, using structural and topological parameters. For the development of models, three methods were used: (1) stepwise regression, (2) factor analysis followed by multiple linear regressions (FA-MLR) and (3) partial least squares (PLS) analysis. The best equation was obtained from stepwise regression analysis (Q2 = 0.626) considering the leave-oneout prediction statistics. [...]
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
6
Numer
2
Strony
267-276
Opis fizyczny
Daty
wydano
2008-06-01
online
2008-04-17
Twórcy
autor
  • Drug Theoretics and Cheminformatics Lab, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, India
  • Drug Theoretics and Cheminformatics Lab, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, India
autor
  • Drug Theoretics and Cheminformatics Lab, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, India, kunalroy_in@yahoo.com
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-008-0014-7
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