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2008 | 6 | 2 | 154-160
Tytuł artykułu

Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Derivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions. [...]
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
6
Numer
2
Strony
154-160
Opis fizyczny
Daty
wydano
2008-06-01
online
2008-04-17
Twórcy
autor
  • Department of Chemistry, Faculty of Science, University of Tanta, 31527, Tanta, Egypt, afafgenady@hotmail.com
  • Department of Chemistry, Faculty of Science, University of Tanta, 31527, Tanta, Egypt
autor
  • Department of Chemistry, University of Bremen, P.O. Box 330440, D-28334, Bremen, Germany
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-008-0008-5
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