Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

• Autorzy: Afaf Genady , Mohamed El-Zaria , Detlef Gabel
• Języki publikacji: EN

Abstrakty

EN

Derivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions. [...]

Słowa kluczowe

EN

Heterocycles; Boranes; Purine; Antitumor agents

• Czasopismo: Open Chemistry
• Rocznik: 2008
• Tom: 6
• Numer: 2
• Strony: 154-160

Daty

wydano

2008-06-01

online

2008-04-17

Twórcy

autor

Afaf Genady

• Department of Chemistry, Faculty of Science, University of Tanta, 31527, Tanta, Egypt,

autor

Mohamed El-Zaria

• Department of Chemistry, Faculty of Science, University of Tanta, 31527, Tanta, Egypt

autor

Detlef Gabel

• Department of Chemistry, University of Bremen, P.O. Box 330440, D-28334, Bremen, Germany

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Identyfikatory

DOI

10.2478/s11532-008-0008-5