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2008 | 6 | 1 | 47-53
Tytuł artykułu

Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
By the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization with 2% NaOH led to the formation of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones 2. The pharmacological effects of 2 on the central nervous system in mice were investigated. Strong antinociceptive properties of the investigated derivatives were observed in a wide range of doses. [...]
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
6
Numer
1
Strony
47-53
Opis fizyczny
Daty
wydano
2008-03-01
online
2008-03-01
Twórcy
autor
  • Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland, agata.siwek@am.lublin.pl
autor
  • Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland
autor
  • Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland
  • Department of Toxicology, Medical University, 20-093, Lublin, Poland
  • Department of Toxicology, Medical University, 20-093, Lublin, Poland
  • Department of Toxicology, Medical University, 20-093, Lublin, Poland
autor
  • Department of Computer Science, Academy of Humanities and Economics in Lodz, 90-222, Lodz, Poland
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-007-0058-0
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