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Czasopismo
2007 | 5 | 3 | 688-705
Tytuł artykułu

Indolyl substituted 4-oxobut-2-enoic acids. Synthesis and aza-Michael additions

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The synthesis of three new substituted 4-hetereoaryl-4-oxobut-2-enoic acids with indole ring substitutedin positions 3-, 5- and 7- is described. The addition of these Michael acceptors to 4-(1-phenylsulphonylpyrrol-3-yl)-4-oxobut-2-enoic acid in conjugate addition was explored using both racemic and chiral amines. In tandem with the crystallization-induced asymmetric transformation (CIAT) protocol the effective methodology for the synthesis of enantiomerically highly enriched substituted 2-amino-4-heteroaryl-4-oxobutanoic acids as multifunctional homotryptophan analogues was developed. [...]
Wydawca

Czasopismo
Rocznik
Tom
5
Numer
3
Strony
688-705
Opis fizyczny
Daty
wydano
2007-09-01
online
2007-04-26
Twórcy
  • Department of Organic Chemistry, Slovak University of Technology, SK-812 37, Bratislava, Slovakia, dusan.berkes@stuba.sk
  • Department of Organic Chemistry, Slovak University of Technology, SK-812 37, Bratislava, Slovakia, anna.korenova@stuba.sk
  • Department of Organic Chemistry, Slovak University of Technology, SK-812 37, Bratislava, Slovakia
  • Department of Organic Chemistry, Slovak University of Technology, SK-812 37, Bratislava, Slovakia
  • Department of NMR spectroscopy and mass spectroscopy, Slovak University of Technology, SK-812 37, Bratislava, Slovakia
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-007-0019-7
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