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2013 | 85 | 11 | 657-662
Tytuł artykułu

The relative frequency of the Helicobacter pylori Infection in Proximal Gastric Cancers

Treść / Zawartość
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Języki publikacji
EN
Abstrakty
EN
Gastric cancer with the annual mortality of 700 000 is the second cause of death in the world. Iran with the annual incidence of 37 in 100 000 is among areas with high risk of gastric cancer. In Iran, Khuzestan Province with the annual incidence of 10 -15 in 100 000 is among areas with moderate risk. The role of Helicobacter pylori infection in distal gastric cancer as one of the most important risk factors of gastric ulcer has been proved but its role in proximal gastric cancer is controversial. In recent decades, the incidence of proximal cancers has increased. The aim of the study was to survey the relative frequency of Helicobacter pylori infection in the people with proximal cancer and to compare it with this infection frequency in the distal cancer. Material and methods. Relative frequency of Helicobacter pylori infection was surveyed by pathology tests and biopsy gastric mucosa sample staining with H&E in the patients with proximal and distal gastric ulcer whose cancers were proved by pathology method and also in the people who were healthy in terms of a gastric cancer. Data were statistically analyzed by frequency tables and chi square test. Results. One hundred and seventeen people entered the study. Among 32 patients with the proximal cancer, 21 people were with the positive Helicobacter pylori (65.6%) and 11 people (34.4%) were with the negative Helicobacter pylori (p<0.01). Among 30 patients with the distal cancer, 26 people were with positive Helicobacter pylori (86.7%) and four people were with negative Helicobacter pylori (13.3%) (p<0.01); 55 people were without the cancer, which among them, 40 people were with the positive Helicobacter pylori (72.7%); and 15 people were with the negative Helicobacter pylori (37.7%) (p<0.01). In comparison of the frequency of Helicobacter pylori infection in the patients with the proximal cancer, a weak significant difference exists (p = 0.053). Comparing the frequency of Helicobacter pylori infection in the patients with the gastric cancer and people without the cancer, no significant difference existed (p = 0.703). Conclusion. A weak significant difference existed between the frequency of Helicobacter pylori infection in patients with the proximal gastric cancer and the frequency of these infections in the patients with the distal cancer. So, eradicating Helicobacter pylori infection can be effective in preventing the distal gastric cancers in addition to preventing the proximal gastric cancers.
Wydawca

Rocznik
Tom
85
Numer
11
Strony
657-662
Opis fizyczny
Daty
wydano
2013-11-01
online
2013-12-31
Twórcy
  • Department of Cancer Surgery, Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences in Ahvaz, Iran
  • Department of Gastroenterology, Imam Khomeini Hospital, Ahvaz, Iran, Iran
  • Department of Cancer Surgery, Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences in Ahvaz, Iran
Bibliografia
  • 1. Nyren O, Adami HO : Stomach Cancer. In: Adami HO, Hunter DJ, Trichopoulos D. Textbook of Cancer Epidemology.2nd ed. England: Oxford university press; 2008; 169-87.
  • 2. Malekzadeh R, Derakhshan MH, Malekzadeh Z: Gastric cancer in Iran: epidemiology and risk factors. Arch Iran Med 2009; 12: 576-83.[PubMed]
  • 3. Parkin DM, Bray F, Ferlay J et al.: Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
  • 4. Sajadjadi A, Malekzadeh R, Derakhshan MH et al.: Cancer occurrence in Ardebil: results of a population based cancer registry from Iran. Int J Cancer 2003; 107(1): 113-18.
  • 5. Mohagheghi M, Mousavi A: First Report of Tehran Population Based Cancer Registry1999-2004. Tehran: The Cancer Institute, Tehran University of Medical Sciences; 2007.
  • 6. Dempsel DT : Stomach in: Brunicardi FC, Anderson DK, Billiar TR, Dunn DL, Hunter GJ, Matthews JB, et al: Schwartz’s principles of surgery.9th ed. New York: MC Graw Hill; 2009; 889-93-96.
  • 7. Blot WJ , Devesa SS , Kneller RW et al.: Rising incidence of adenocarcinoma of the esophagus and gastric cardiac. JAMA 1991; 265: 1287.
  • 8. First Report of Tehran Papulation Based Cancer Registry1999-2004 Powell J, McConkey CC: Increasing incidence of adenocarcinoma of the gastric cardiac and adjacent sites. Br J Cancer 1990; 62: 440.
  • 9. Correa P, Haenszel W, Cuello C et al.: A model for gastric cancer epidemiology. Lancet 1975; 2: 58 -60.[PubMed][Crossref]
  • 10. Marshall BJ: History of the discovery of C. pylori. In: Blaser, MJ.Campylobacter Pylori in Gastritis and Peptic Ulcer Disease.2nd. New York: Igaku-Shoin 1989; 7.
  • 11. Goodwin CS , Worsley BW: Microbiology of Helicobacter pylori. Gastroenterol Clin North Am 1993; 22: 5.[PubMed]
  • 12. Cave DR : Transmission and epidemiology of Helicobacter pylori. Am J Med 1996; 100: 12S.[PubMed][Crossref]
  • 13. Kato M, Asaka M, Shimizu Y et al.: Relationship between Helicobacter pylori infection and the prevalence, site and histological type of gastric cancer. Aliment Pharmacol Ther 2010; 20 Suppl 1: 85-89.
  • 14. Sotoudeh M, Derakhshan MH, Abedi-Ardakani B et al.: Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardiac cancer. Dig Dis Sci 2008; 53: 27-33.[Crossref][WoS]
  • 15. Wu AH , Crabter JE , Bernstein L et al.: Role of Helicobacter pylori CagA+ Strain and Risk of Adenocarcinoma of the Esophagus. Int J Cancer 2003; 103: 815-21.
  • 16. Kamangar F, Dawsey SM, Blaser MJ et al.: Opposing risks of gastric cardiac and noncardiac gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst 2006; 98: 1445-52. [Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_pjs-2013-0099
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