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2013 | 85 | 8 | 446-451
Tytuł artykułu

Colorectal Cancer in Young and Elderly Patients

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of the study was to answer the question whether there are differences in the progression of the disease and its morphology, dependent of the patient’s age, as well as show colorectal cancer differences between young and elderly patients. Material and methods. During the period between 2009 and 2011, 747 patients with rectal carcinoma, and 478 with colon cancer underwent surgery at the Department of General and Colorectal Surgery. The study group comprised patients under the age of 40 years (56 patients) and >80 years (90 patients). The following were subject to analysis: gender, tumor location, percentage of radical and palliative procedures, clinical and histopathological staging, as well the differences in the morphology of the tumor. The χ2 test and Yates’ correction were used for statistical analysis. p<0.05 was considered as statistically significant. Results. A higher incidence of rectal carcinoma was observed in younger patients (p=0.004). Amongst the younger patients 30.3% were diagnosed with stage III cancer, while 35.7% with stage IV. In case of elderly patients 30.6% were diagnosed with stage III cancer, while 30.7% with stage IV. In 53.3% of young patients, local lymph node metastases were observed, while in the elderly 41.8%. No statistically significant difference was observed, considering the total number of lymph nodes metastases. However, in case of stage N2, results were unfavorable for young patients 31.8% vs 17% in case of the elderly. Mucogenic adenocarcinoma incidence was similar in both groups. In case of patients< 40 years we observed a higher incidence of poorly differentiated tumors, as compared to the elderly patients (>80 years). Conclusions. 1. It is necessary to create appropriate prevention programs for young community, and improvement of public awareness in this age group. 2. Colorectal cancer (CRC) in young patients is often recognized in advanced stage. 3. A high percentage of unresectable tumors in group of elderly patients shows that CRC is still diagnosed too late in Poland.
Wydawca

Rocznik
Tom
85
Numer
8
Strony
446-451
Opis fizyczny
Daty
wydano
2013-08-01
online
2013-09-05
Twórcy
autor
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of General and Colorectal Surgery, Medical University in Łódź
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź
Bibliografia
  • 1. Halczak M, Wojtasik P, Al-Amawi T, Kładny J: Elektywne resekcje ogniska pierwotnego u chorych na raka odbytnicy w IS stopniu zaawansowania klicznicznego - doświadczenia własne. Pol PrzeglChir 2011; 83(7): 677-84.
  • 2. http://www.onkologia.org.pl/pl/p/7/
  • 3. Kuliński A, Kamocki Z, Cepoiwcz D i wsp.: Związek między insulinopodobnym czynnikiem wzrostu 1 oraz wybranymi parametrami klinicznomorfologicznymi u chorych na raka jelita grubego. Pol Przegl Chir 2011; 83(5): 445-68.
  • 4. Cook AD, Single R, McCahill LE : Surgical resection of primary tumors in patients who present with stage IV colorectal cancer: an analysis of surveilence, epidemiology, and end results data 1988 to 2000. Ann Surg Oncol 2005; 12: 637-45.
  • 5. Mandel J, Bond J, Church T et al.: Reducing mortality from colorectal cancer by screening for fecal occuolt blood. N Eng J Med 1993; 13: 1365.[Crossref]
  • 6. Mroczkowski P, Hać S, Mik M i wsp.: Wyniki pilotażowe pierwszego programu badania jakości leczenia raka odbytnicy w Polsce. Pol Przegl Chir 2011; 83(3): 265-73.
  • 7. Berrino F, De AR, Sant M et al.: Survival for eight major cancers and al. cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol 2007; 8(9): 773-83.[WoS]
  • 8. Berrino F, Verdecchia A, Lutz JM et al.: Comparative cancer curvival information in Europe. Eur J Cancer 2009; 45(6): 901-08.[Crossref][WoS]
  • 9. O’Connell JB, Maggard MA, Livingston EH , YoCK : Colorectal cancer in the young. Am J Surg 2004; 187(3): 343-48.[Crossref]
  • 10. Zbuk K, Sidebotham EL , Bleyer A, La QuagliaMP: Colorectal cancer in young adults. Semin Oncol 2009; 36(5): 439-50.[WoS][PubMed][Crossref]
  • 11. O’Connell JB, Maggard MA, Liu JH et al.: Rates of colon and rectal cancers are increasing in young adults. Am Surg 2003; 69(10): 866-72.
  • 12. Shemesh-Bar L, Kundel Y, Idelevich E et al.: Colorectal cancer in young patients in Israel: a distinct clinicopathological entity? World J Surg 2010; 34(11): 2701-09.[Crossref]
  • 13. Ganapathi S, Kumar D, Katsoulas N et al.: Colorectal cancer in the young: trends, characteristics and outcome. Int J Colorectal Dis 2011; 26(7): 927-34.[Crossref]
  • 14. O’Connell JB, Maggard MA, Liu JH et al.: Do young colon cancer patients have worse outcomes? World J Surg 2004; 28(6): 558-62.[Crossref]
  • 15. Kansakar P, Singh Y: Changing trends of colorectal carcinoma in Nepalese young adults. AsianPac J Cancer Prev 2012; 13(7): 3209-12.[WoS]
  • 16. Zaręba K, Bandurski R, Kędra B: Young patient age as the cause of delayed diagnosis of gastrointestinal carcinoma. Pol Przegl Chir 2012; 84(6): 317-21.[PubMed]
  • 17. Maciel de Fosa L, Profeta de Luz M, Lacerda-Filho A et al.: Colorectal carcinoma in difrent age groups. A histopatological analysis. Int J ColorectalDis 2012; 27(2): 249-55.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_pjs-2013-0068
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