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2013 | 85 | 5 | 284-288
Tytuł artykułu

Gastric High-Risk Gist and Retroperitoneal Liposarcoma – A Challenging Combination of Two Mesenchymal Tumor Lesions with Regard to Diagnosis and Treatment

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Both gastrointestinal stromal tumors (GIST) and liposarcoma originate from mesenchymal tissue. Their coincidence requires a specific expertise in the diagnostic and therapeutic management. An unusual exemplary case is described representing a 47-year old female patient with a gastric GIST and a monstrous retroperitoneal liposarcoma with infiltration of the left kidney. The gastric tumor lesion was removed with a tangential resection of the gastric wall; the retroperitoneal tumor lesion was resected including the left kidney. Both tumors were resected with no macroscopic tumor residual. The technically difficult surgical intervention did not show any postoperative complication, and the postoperative course was also uneventful. The complete tumor resection is the treatment of choice in mesenchymal tumors (aim: R0). Depending on histologic tumor classification, resection status and tumor sensitivity, a subsequent radiation and/or chemotherapy is necessary, which allowed to achieve a postoperative tumor-free survival of 6 years including a good quality of life.
Słowa kluczowe
Wydawca

Rocznik
Tom
85
Numer
5
Strony
284-288
Opis fizyczny
Daty
wydano
2013-05-01
online
2013-06-12
Twórcy
autor
  • Department of Surgery, Otto-von-Guericke University in Magdeburg, Germany
  • Institute of Pathology, Otto-von-Guericke University in Magdeburg, Germany
  • Institute of Pathology, Otto-von-Guericke University in Magdeburg, Germany
autor
  • Department of Surgery, Otto-von-Guericke University in Magdeburg, Germany
autor
  • Department of Surgery, Otto-von-Guericke University in Magdeburg, Germany
Bibliografia
  • 1. Comandone A, Boglione A: Biology, diagnosis and therapeutic options in gastrointestinal stromal tumours. Minerva Chir 2005; 60(5): 197-203.[PubMed]
  • 2. Fletcher CD, Bermann JJ, Corless C et al.: Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002; 33: 459-65.[PubMed][Crossref]
  • 3. Hohenberger P, Wardelmann E: Surgical conciderations for gastrointestinal stroma tumor. Chirurg 2006; 77: 33-40.[Crossref]
  • 4. Stamatakos M, Douzinas E, Stefanaki C et al.: Gastrointestinal stromal tumor. WJSO 2009; 7: 61.
  • 5. Schildhaus HU, Merkelbach-Bruse S, Büttner R,Wardelmann E: Pathology and molecular biology of gastrointestinal stromal tumors (GIST). Radiologe 2009; 49(12): 1104.[WoS][PubMed][Crossref]
  • 6. Bai YK, Shao YF, Shi SS: Analysis of prognostic factors in gastrointestinal stromal tumours of the small intestine. Zhonghua WCWKZZ 2005; 8: 213-16.[PubMed]
  • 7. Urbancyk K, Limon L, Korobowicz E: Gastrointestinal stromal tumors. A multicenter experience. Pol J Pathol 2005; 56(2): 51-61.
  • 8. Blay JY, Bonvalot S, Casali P et al.: GIST consensus meeting panellists, Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol 2005; 16(4): 566-78.
  • 9. DeMatteo RP, Gold JS, Saran L et al.: Tumor mitotic rate, size and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer 2008; 112: 608-15.[Crossref]
  • 10. Miettinen M, Lasota J: Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006; 23: 70-83.[Crossref][PubMed]
  • 11. Nakamura N, Yamamoto H, Yao T: Prognostic significance of expressions of cell-cycle proteins in gastrointestinal stromal tumor and relevance of the risk grade. Hum Pathol 2005; 36(7): 828-37.[Crossref][PubMed]
  • 12. Wilmans C, Eggstein S, Ruf G: Score Prediction of Metastatic Risk in Gastrointestinal Stromal Tumours (GIST). Zentralbl Chir 2007; 132: 509-14.
  • 13. Jie ZG, Xie XP, Qin KW et al.: Clinical analysis of prognostic factors for patients with gastrointestinal stromal tumors. Zhonghua WCWKZZ 2005; 8(3): 210-12.[PubMed]
  • 14. Miettinen M, Sobin LH, Lasota J: Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am JSurg Pathol 2005; 29: 52-68.[Crossref]
  • 15. Agaimy A, Wuensch PH: Gastrointestinal stromal tumours in patients with other-type cancer, a mere coincidence or an etiological association? A study of 97 GIST cases. Z Gastroenterol 2005; 43(9): 1025-30.[PubMed]
  • 16. Clary BM, Dematteo RP, Lewis JJ et al.: Gastrointestinal stromal tumors and leiomyosarcoma of the abdomen and retroperitoneum: a clinical comparison. Ann Surg Oncol 2001; 8(4): 290-99.[PubMed][Crossref]
  • 17. Ruka W, Rutkowski P, Nowecki Z, Nasierowska-Guttmejer A: Other malignant neoplasms in patients with gastrointestinal stromal tumors. MedSci Monit 2004; 10(8): LE13-14.[PubMed]
  • 18. Benseler V, Obed A, Schubert T et al.: Case Report - Surgical Therapy of a Retroperitoneal Liposarcoma Weighing 45 kg. Zentralbl Chir 2009; 134: 174-77.
  • 19. Gockel I, Oberholzer K, Gönner U et al.: Retroperitoneal Sarcomas: Diagnostic and Therapy. Zentralbl Chir 2006; 131: 223-29.
  • 20. Wente MN, Büchler MW, Weitz J: Gastrointestinale Stromatumoren (GIST). Chirurg 2008; 79: 638-43.[Crossref]
  • 21. Nishida T, Hirota S: Biological and clinical review of stromal tumors in the gastrointestinal tract. Histol Histopathol 2000; 15: 1293-301.[PubMed]
  • 22. Reichardt P, Reichardt A: Gastrointestinaler Stromatumor (GIST): Aktueller Stand der multimodalen Therapie. Zentrabl Chir 2011; 136(04): 359-63.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_pjs-2013-0043
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