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2013 | 85 | 5 | 271-278
Tytuł artykułu

Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Abdominal aortic aneurysms and abdominal hernias become an important health problems of our times. Abdominal aortic aneurysm and its rupture is one of the most dangerous fact in vascular surgery. There are some theories pointing to a multifactoral genesis of these kinds of diseases, all of them assume the attenuation of abdominal fascia and abdominal aortic wall. The density and continuity of these structures depend on collagen and elastic fibers structure. Reducing the strengthof the fibersmaybedue to changes in the extracellular matrix (ECM) by the proteolytic enzymes-matrix metalloproteinases (MMPs) that degrade extracellular matrix proteins. These enzymes play an important role in the development of many disease: malignant tumors (colon, breast, lung, pancreas), cardiovascular disease (myocardial infarction, ischemia-reperfusion injury), connective tissue diseases (Ehler-Danlos Syndrome, Marfan’s Syndrome), complications of diabetes (retinopathy, nephropathy). One of the most important is matrix metalloproteinase-2 (MMP-2). The aim of the study was an estimation of the MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia, and in patients with only abdominal aortic aneurysm. Material and methods. The study involved 88 patients aged 42 to 89 years, including 75 men and 13 women. Patients were divided into two groups: patients with abdominal aortic aneurysm and primary abdominal hernia (45 persons, representing 51.1% of all group) and patients with only abdominal aortic aneurysm (43 persons, representing 48,9% of all group). Results. It was a statistically significant increase in MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia compared to patients with only abdominal aortic aneurysm. It was a statistically significant increase in the prevalence of POCHP in patients with only abdominal aortic aneurysm compared to patients with abdominal aortic aneurysm and primary abdominal hernia. Conclusions. Statistically significant higher MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia seems shows that this enzyme plays a role in the pathogenesis of primary abdominal hernias. The observed distribution of MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia may raise the conclusion that this enzyme determines the presence of multi-organ failure of the connective tissue - the patients with only abdominal aortic aneurysm had significantly lower MMP-2 blood levels.
Wydawca

Rocznik
Tom
85
Numer
5
Strony
271-278
Opis fizyczny
Daty
wydano
2013-05-01
online
2013-06-12
Twórcy
  • Department of General and Vascular Surgery, M. Pirogow Hospital in Łódź. Ordynator: dr n. med. J. Okraszewski. Opiekun naukowy pracy: prof. dr hab. K. Kuzdak
Bibliografia
  • 1. Sołtysiak A (opracowanie zbiorowe): Tętniaki aorty brzusznej. Wyd. I. Drukarnia Wydawnictw Naukowych S.A., Łódź 2000.
  • 2. Noszczyk W (opracowanie zbiorowe): Chirurgia tętnic i żył obwodowych. Wyd. II. Wydawnictwo Lekarskie PZWL, Warszawa 2007.
  • 3. Annabi B, Shedid D, Ghosn P et al.: Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. J Vasc Surg 2002; 35(3): 539-46.[Crossref]
  • 4. Lee HY, Oh BH: Aging and arterial stiffness. CircJ 2010; 74(11): 2257-62[WoS]
  • 5. Lakatta GE: Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part III: cellular and molecular clues to heart and arterial aging. Circ 2003; 28: 107(3): 490-97.
  • 6. Wilson WRW , Schwalbe EC , Jones JL et al.: Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm. Br J Surg 2004; 92(7): 828-33.
  • 7. Abdul-Hussien H, Soekhoe RGV, Weber E et al.: Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinases and cysteine collagenases. Am J Pathol 2007; 170(3): 809-17.[WoS]
  • 8. Lakatta GE: Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a “set up” for vascular disease. Circ 2003 7; 107(1): 139-46.
  • 9. Pascual G, Rodriguez M, Gomez-Gil V et al.: Active matrix metalloproteinase-2 upregulation in the abdominal skin of patients with direct inguinal hernia. Eur J Clin Invest 2010; 40(12): 1113-21.[Crossref][WoS]
  • 10. Burcharth J, Rosenberg J: Hernias as medical disease. Ugeskr Laeger 2008 13; 170(42): 3314-18.
  • 11. Aren A, Gokce AH, Gokce FS, Dursun N: Roles of matrix metalloproteinases in the etiology of inguinal hernia. Hernia 2011; 15(6): 667-71.[PubMed][WoS][Crossref]
  • 12. Antoniou GA, Tentes IK , Antoniou SA et al.: Matrix metalloproteinase imbalance in inguinal hernia formation. J Invest Surg 2011; 24(4): 145-50.[Crossref][WoS]
  • 13. Jain V, Srivastava R, Jha S et al.: Study of matrix metalloproteinase-2 in inguinal hernia. JClin Med Res 2009; 1(5): 285-89.
  • 14. Bellon JM, Bajo A, Ga-Honduvilla N et al.: Fibroblasts from the transversalis fascia of young patients with direct inguinal hernias show constitutive MMP-2 overexpression. Ann Surg 2001; 233(2): 287-91.
  • 15. Szczęsny W, Dąbrowiecki S: Współczesne poglądy na etiopatogenezę przepuklin ściany brzucha. Chirurgia Polska 2005, 7; (4): 280-86.
  • 16. Śmigielski J, Brocki M, Kuzdak K, KołomeckiK: Serum MMP-2 and TIMP-2 in patients with inguinal hernias. Eur J Clin 2011; 41(6): 584-88.[Crossref][WoS]
  • 17. Śmigielski J, Kołomecki K, Ziemniak P et al.: Degradation of collagen by metalloproteinase-2 in patients with abdominal hernias. Eur Surg Res 2009; 42(2): 118-21.[Crossref][WoS]
  • 18.Creager Mark A, Dzau Victor J, Loscalzo J: Choroby naczyń. Podręcznik towarzyszący do Braunwald’s heart disease. Wyd. I. Wydawnictwo Czelej, Lublin 2008.
  • 19. Kaneko H, Anzai T, Takahashi T et al.: Role of vascular endothelial growth factor - A in development of abdominal aortic aneurysm. CardiovascRes 2011 91, 358-67.
  • 20. Kandasamy AD, Chow AK , Ali M, Schulz R: Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix. CardiovascRes 2010; 85: 413-23.
  • 21.Viappiani S, Nicolescu AC , Holt A et al.: Activation and modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. BiochemPharmacol 2009; 77: 826-34.[WoS]
  • 22. Siefert SA, Sarkar R: Matrix metalloproteinases in vascular physiology and disease. Vascular 2012; 20(4): 210-16.[PubMed][Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_pjs-2013-0041
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