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Tytuł artykułu

Top-down peptidomics of bodily fluids

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EN
Abstrakty
EN
The naturally occurring peptides, mainly arising from the proteolytic cleavage of larger proteins, play several functions within the body (e. g. antihypertensive, immuno-modulatory, anti-microbial and antiviral, mineral carriers). Their presence or the increase of their concentration could be connected to different pathologies and thereby some peptides could be useful biomarkers for the diagnosis or prognosis of the disease. Peptidome research, particularly within biological fluids, therefore represents one of the most interesting and challenging purposes of proteomics. In this review we describe the current state-of-the-art in peptidomics-based studies of several human bodily fluids (serum, plasma, urine, cerebrospinal fluid, saliva, tears, seminal fluid, vitreous humor, pancreatic juice), emphasizing the contribution of top-down proteomic platforms to the deep structural characterization of natural peptides and their posttranslational modifications.
Wydawca

Czasopismo
Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2013-12-05
zaakceptowano
2014-03-28
online
2014-07-09
Twórcy
  • Istituto di Biochimica
    e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
    Sacro Cuore, Largo F. Vito, 00168, Roma, Italy
  • Istituto di Biochimica
    e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
    Sacro Cuore, Largo F. Vito, 00168, Roma, Italy
  • Istituto di Biochimica
    e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
    Sacro Cuore, Largo F. Vito, 00168, Roma, Italy
  • Dipartimento di
    Scienze della Vita e dell‘Ambiente, Università di Cagliari, Monserrato
    (CA), Italy
  • Dipartimento di
    Scienze della Vita e dell‘Ambiente, Università di Cagliari, Monserrato
    (CA), Italy
  • Istituto di Chimica del
    Riconoscimento Molecolare – UOS Roma, Consiglio Nazionale delle
    Ricerche, Roma, Italy
  • Dipartimento di
    Scienze della Vita e dell‘Ambiente, Università di Cagliari, Monserrato
    (CA), Italy
  • Istituto di Biochimica
    e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
    Sacro Cuore, Largo F. Vito, 00168, Roma, Italy, massimo.castagnola@icrm.cnr.it
  • Istituto di Chimica del
    Riconoscimento Molecolare – UOS Roma, Consiglio Nazionale delle
    Ricerche, Roma, Italy
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