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Tytuł artykułu

Chitosan microgels obtained by on-chip crosslinking reaction employing a microfluidic device

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In the present work, we report on the preparation of microgels of chitosan crosslinked with sodium tripolyphosphate (TPP) employing the microfluidics technique (MF). To achieve this, several flow focusing geometries were designed and tested. As a first step, a two-inlet flow focusing geometry was employed to emulsify chitosan and the crosslinking reaction was carried out offchip. This procedure did not allow separating the resulting chitosan microgels due to an incomplete crosslinking reaction. A crosslinking reaction on-chip was studied as an alternative. A four-inlet flow focusing geometrywas designed in which three dispersed phases, chitosan 0.25% (w/v), TPP 0.05% (w/v) and acetic acid 1% (v/v) and an continuous phase mineral oil + Span 80 (3% w/v) were employed. The flow rates for the continuous phase were varied from 6.7 to 11.7 μL/min and chitosan microgels were successfully obtained with average diameters from 68 to 42 μm. The average size of the microgels outside the MF device decreased up to ~21% with respect to their size inside the MF device due to partial expulsion of water from the microgels when complete gelation occurred.
Słowa kluczowe
Wydawca

Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2014-06-30
zaakceptowano
2014-09-19
online
2014-12-18
Twórcy
  • Institute of Polymer
    Science and Technology, The Spanish National Research Council
    (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
  • Department of Chemistry, University of Toronto, 80 Saint
    George Street, Toronto, Ontario M5S 3H6, Canada
  • Department of Chemistry, University of Toronto, 80 Saint
    George Street, Toronto, Ontario M5S 3H6, Canada
  • Department of Bioengineering, Universidad Carlos III de
    Madrid, Spain. Instituto de Investigación Sanitaria de la Fundación
    Jiménez Díaz, Madrid, Spain
  • Institute of Polymer
    Science and Technology, The Spanish National Research Council
    (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain, rhernandez@ictp.csic.es
  • Institute of Polymer
    Science and Technology, The Spanish National Research Council
    (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
  • Department of Chemistry, University of Toronto, 80 Saint
    George Street, Toronto, Ontario M5S 3H6, Canada
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_optof-2014-0004
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