Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 1 | 1 |
Tytuł artykułu

Contrast-phase Imaging of Fixed-Cells through Micro-Cavity Scanning Microscopy

Treść / Zawartość
Warianty tytułu
Języki publikacji
Contrast phase imaging at infrared wavelengths is achieved through an extrinsic Fabry-Perot cavity in optical fiber. The micro-cavity is realized by approaching a cleaved fiber to a distance of about few tens of microns from the surface under test. The probe is a single mode fiber and is fed by a low-coherence source. The information is extracted from the reflected spectrum, that starts to be modulated by the interference when the fiber begins to interact with the sample. The measurement of the reflected optical intensity provides a map of the sample reflectivity, whereas from the analysis of the spectrum in the time/spatial domain, it is possible to extract topography and refractive index variations. This information is entangled in the contrast phase image obtained. In this work we review the system proposed in [19] in order to extract topography and local surface permittivity of biological samples. The system displays tridimensional images with a transverse resolution that is not limited by the numerical aperture NA of the scanning probe (as suggested by the Rayleigh limit), but it is related to the transverse field behavior of the electromagnetic field inside the micro-cavity. Differently, the source bandwidth, demodulation algorithm and optical spectrum analyzer resolution affect the resolution in the normal direction.

Opis fizyczny
  • Dipartimento di Ingegneria
    dell’Informazione, Università Politecnica delle Marche,
    Ancona, 60131, Italy
  • Dept. of Neuroscience and Imaging, Università “G.
    d’Annunzio’, Via dei Vestini, 66013, Chieti Italy
  • Dip. di Scienze Chimiche e Farmaceutiche, Università di
    Trieste,Via Valerio, 34127, Trieste
  • Dipartimento di Ingegneria
    dell’Informazione, Università Politecnica delle Marche,
    Ancona, 60131, Italy
  • Dipartimento di Ingegneria
    dell’Informazione, Università Politecnica delle Marche,
    Ancona, 60131, Italy
  • [1] Bing Yu et al. “Analysis of Fiber Fabry-Perot InterferometricSensors Using Low-Coherence Light Sources,” IEEE Journal ofLightwave Technology, vol. 24 , No. 4, April 2006, pp. 1758 –1767.[Crossref]
  • [2] K. A. Murphy, M. F. Gunther, A. Wang, R. O. Claus, and A. M.Vengsarkar, "Extrinsic Fabry–Pérot optical fiber sensor", inProc. 8th Opt. Fiber Sens. Conf., 1992, pp.193 -196.
  • [3] N. Furstenau, M. Schmidt, H. Horack, W. Goetze, and W.Schmidt, "Extrinsic Fabry–Pérot interferometer vibrationand acoustic systems for airport ground traffic monitoring",in Proc. Inst. Elect. Eng.-Optoelectron., vol. 144, No. 3, 1997,pp.134 -144.
  • [4] A. Wang, H. Xiao, J. Wang, Z. Wang, W. Zhao, and R. G. May,"Self-calibrated interferometric-intensity-based optical fibersensors", IEEE Journal of Lightwave Technology, vol. 19, No.10, pp.1495 -1501, 2001[Crossref]
  • [5] H.-Y. Yao and T.-H. Chang, "Experimental and TheoreticalStudies of a Broadband Superluminality in Fabry-Perot Interferometer",Progress In Electromagnetics Research, vol. 122,pp. 1-13, 2012.[WoS]
  • [6] F. Costa and A. Monorchio, “Design of Subwavelength Tunableand Steerable Fabry-Perot/Leaky Wave Antennas”,Progress In Electromagnetics Research , vol. 111, pp. 467-481,2011.[WoS]
  • [7] M. Han, Y. Zhang, F. Shen, G. R. Pickrell, A. Wang, "Signalprocessingalgorithm for white-light optical fiber extrinsicFabry-Perot interferometric sensors", Optics Letters, vol. 29,No.15, pp. 1736-1738, August 2004.[Crossref]
  • [8] J. H. Chen, J. R. Zhao, X. G. Huang, Z. J. Huang, "Extrinsicfiber-optic Fabry-Perot interferometer sensor for refractiveindex measurement of optical glass", Applied Optics, vol.49,No. 29, pp. 5592-5596, October 2010.[Crossref]
  • [9] Xinlei Zhou and Qingxu Yu, "Wide-Range Displacement SensorBased on Fiber-Optic Fabry–Perot Interferometer for SubnanometerMeasurement", IEEE Sensors Journal, vol. 11 , No.7, pp. 1602 – 1606, July 2011.[WoS][Crossref]
  • [10] Y. Zhang, H. Shibru, K. L. Cooper and A. Wang, "Miniaturefiber-optic multicavity Fabry-Perot interferometric biosensor",Optics Letters, vol. 30, No. 9, pp. 1021-1023, May 2005.[Crossref]
  • [11] P. R. Wilkinson and J. R. Pratt, "Analytical model for low fi-nesse, external cavity, fiber Fabry–Perot interferometersincluding multiple reflections and angular misalignment",Applied Optics, Vol. 50, No. 23, pp. 4671-4680, August 2011.[WoS][Crossref]
  • [12] O. Kilic, Michel J. F. Digonnet, Gordon S. Kino and O. Solgaard,"Asymmetrical Spectral Response in Fiber Fabry–PérotInterferometers", IEEE Journal of Lightwave Technology, Vol.27, No. 24, pp. 5648-5656, December 2009.[WoS][Crossref]
  • [13] D. J. Daniels, Ground Penetrating Radar, 2nd edition, IET,London, 2007.
  • [14] B. Bouma, and G. Tearney, Handbook of Optical CoherenceTomography, Marcel Dekker, 2002.
  • [15] S. O. Isikman et al., “Lensfree On-Chip Microscopy and Tomographyfor Biomedical Applications”, IEEE Journal of SelectedTopics in Quantum Electronics, vol. 18 , No. 3, pp. 1059– 1072, May-June 2012.[Crossref][WoS]
  • [16] A. Di Donato et al., “Using Correlation Maps in a Wide-bandMicrowave GPR”, Progress In Electromagnetics Research B,Vol. 30, pp. 371-387, 2011.
  • [17] M. Farina et al. “Disentangling time in a near-field approachto scanning probe microscopy”, Nanoscale, vol. 3(9),pp.3589-93, Sep 2011.
  • [18] M. Farina, et al., “Algorithm for reduction of noise in ultramicroscopyand application to near-field microwave microscopy,"IET Elect. Lett., Vol. 46, No. 1, 50-52, Jan. 2010.
  • [19] A. Di Donato, A. Morini, and M. Farina, “Optical Fiber ExtrinsicMicro-Cavity Scanning Microscopy”, Progress In ElectromagneticsResearch, Vol. 133, pp. 347-366, 2013.[WoS]
  • [20] S. O. Isikman et al., “Lensfree On-Chip Microscopy and Tomographyfor Bio-Medical Applications”, IEEE Journal of SelectedTopics in Quantum Electronics (2011).[WoS]
  • [21] A. Di Donato, T. Pietrangelo, T. Da Ros, T. Monti, D. Mencarelli,G. Venanzoni, A. Morini and M. Farina, “Infrared imagingof fixed-cells through micro-cavity fiber optic scanning microscopy”,Proc. SPIE 8797, 87970I (2013).
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.