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2014 | 59 | 3 | 91-95
Tytuł artykułu

Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The enzymatic deamination of 5-fl uorotryptamine and 5-hydroxytryptamine, 5-HT, catalysed by enzyme monoamine oxidase A (MAO-A, EC 1.4.3.4) was investigated using the kinetic (KIE) and solvent (SIE) isotope effects methods. The numerical values of deuterium isotope effects in the (1R) positions of 5-F-tryptamine were determined using non-competitive spectrophotomeric method. Isotopologue 5-F-[(1R)- -2H]-tryptamine, needed for kinetic studies was obtained by enzymatic decarboxylation of 5´-fl uoro-L-tryptophan, 5´-F-L-Trp, in fully deuteriated medium.
Wydawca

Czasopismo
Rocznik
Tom
59
Numer
3
Strony
91-95
Opis fizyczny
Daty
wydano
2014-08-01
otrzymano
2013-03-01
zaakceptowano
2014-06-26
online
2014-09-12
Twórcy
  • Department of Chemistry, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland, Tel.: +48 22 822 0211 ext. 509, Fax: +48 22 822 0211 ext. 434
  • Department of Chemistry, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland, Tel.: +48 22 822 0211 ext. 509, Fax: +48 22 822 0211 ext. 434, mkanska@chem.uw.edu.pl
Bibliografia
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  • 23. Parkin, D. W. (1991). Methods for determination of competitive and noncompetitive Kinetic Isotope Effects. In P. F. Cook (Ed.) Enzyme mechanism from isotope effects (pp. 269-290). Boca Raton: CRC Press.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_nuka-2014-0015
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