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Czasopismo
2014 | 59 | 3 | 105-110
Tytuł artykułu

The relationship between the alkaline phosphatase network and the haematopoiesis in mice subjected to whole-body irradiation

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Purpose: To investigate the relationship between the alkaline phosphatase (ALP) network of the marrow stroma and the haematopoietic regeneration after mice whole-body irradiation. Materials and methods: Three groups of mice were irradiated with a non-lethal ionising radiation dose: the fi rst one received an intraperitoneal injection of Levamisole, ALP inhibitor, 24 h before irradiation; the second one received an intraperitoneal injection of Lisinopril, haematopoiesis inhibitor, 24 h before irradiation; the third was left untreated, but irradiated. The fourth group, untreated and not irradiated, was the control. The total surface occupied by ALP positive processes, revealed by means of ALP cytochemistry in the marrow area, was evaluated semi-quantitively. Nucleated bone marrow cells were also counted. Results: ALP network began to increase 24 h after irradiation to reach a maximum after 72 h, when the bone marrow was almost become completely empty of the haematopoietic cells. This increase advances the haematopoietic recovery. This process was substantially delayed when the mice were injected with Levamisole 24 h before irradiation. On the contrary, ALP network increased strongly since the fi rst day after irradiation when the mice were injected with Lisinopril 24 h before irradiation. Conclusions: These data have indicated that the haematopoietic recovery and repopulation of the bone marrow were advanced by the ALP network recovery.
Wydawca

Czasopismo
Rocznik
Tom
59
Numer
3
Strony
105-110
Opis fizyczny
Daty
wydano
2014-08-01
otrzymano
2014-02-20
zaakceptowano
2014-06-11
online
2014-09-12
Twórcy
  • Hematological Diseases Laboratory, Department of Radiation Medicine, Atomic Energy Commission of Syria (AECS), P. O. Box 6091 Damascus, Syria, Tel.: +963 11 213 2580, Fax: +963 11 611 2289, ascientific@aec.org.sy
  • Hematological Diseases Laboratory, Department of Radiation Medicine, Atomic Energy Commission of Syria (AECS), P. O. Box 6091 Damascus, Syria, Tel.: +963 11 213 2580, Fax: +963 11 611 2289
Bibliografia
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  • 6. Westen, H., & Baiton, D. F. (1979). Association of alkaline-phosphatase-reticulum cells in bone marrow with granulocytic precursors. J. Exp. Med., 150, 919-937.
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  • 8. Bianco, P., Bradbeer, J. N., Riminucci, M., & Boyde, A. (1993). Marrow stromal (Western-Bainton) cells: identifi cation, morphometry, confocal imaging and changes in disease. Bone, 14, 315-320.[Crossref]
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  • 10. Almohamad, K., Thiry, A., Hubin, F., Belaid, Z., Humblet, C., Boniver, J., & Defresne, M. -P. (2003). Marrow stromal cell recovery after radiation-induced aplasia in mice. Int. J. Radiat. Biol., 79(4), 259-267.
  • 11. Rousseau-Plasse, A., Wdzieczak-Bakala, J., Lenfant, M., Ezan, E., Robinson, S., Briscoe, C. V., Melville, J., & Riches, A. (1998). Lisinopril, an angiotensin I-converting enzyme inhibitor, prevents entry of murine hematopoietic stem cells into the cell cycle after irradiation in vivo. Exp. Hematol., 26, 1074-1079.
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  • 13. Scher, B. M., Fuksina, I., Hellinger, N., Waxman, S., & Scher, W. (1998). The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis. Int. J. Oncol., 12, 987-996.[PubMed]
  • 14. Bianco, P., Costantini, M., Dearden, L. C., & Bonucci, E. (1988). Alkaline phosphatase positive precursors of adipocytes in the human bone marrow. Br. J. Haematol., 68, 401-403.
  • 15. Prince, M. H., Simmons, P. J., Whitty, G., Wall, D. P., Barber, L., Toner, G. C., Seymoour, R. F., Richardson, G., Mrongovius, R., & Haylock, D. N. (2004). Improved hematopoietic recovery following transplantation with ex vivo-expanded mobilized blood cells. Br. J. Haematol., 126(4), 536-545.
  • 16. Haot, J., & Barakina, N. F. (1969). Quantitative study of the hemopoietic recovery after a sublethal X-irradiation in the mouse. Acta Haematol., 42, 347-356.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_nuka-2014-0012
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