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Tytuł artykułu

Molecularly imprinted microspheres prepared by precipitation polymerization at high monomer concentrations

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Highly crosslinked polymer microparticles have been prepared by precipitation polymerization using high monomer loadings (≥25 v/v %) which generally would lead to bulk monoliths. The microparticle format was achieved by the use of non-solvating diluents either alone or in combination with co-solvents. Two distinct morphologies were observed. Monodisperse smooth microspheres were obtained using a thermodynamically good co-solvent whereas segmented irregular particles were formed with poorer co-solvents. It has been found that during polymerization the forming polymer particles were enriched in the co-solvent and this effect was more pronounced when good co-solvents were used. The type of functional monomer, crosslinker and co-solvent, and the non-solvent/co-solvent ratio were identified as influential parameters on the microparticle morphology. With the proposed methodology molecularly imprinted microparticles have been prepared successfully for three different templates, naproxen, diclofenac and toltrazuril using various functional monomers, crosslinkers and polymerization solvent mixtures.
Wydawca

Rocznik
Tom
2
Numer
1
Opis fizyczny
Daty
wydano
2014-01-01
otrzymano
2014-03-10
zaakceptowano
2014-04-23
online
2014-05-21
Twórcy
  • Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4., H-1111, Budapest, Hungary
  • Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary
  • MTA-BME Research Group of Technical Analytical Chemistry, Szt. Gellért tér 4., H-1111, Budapest, Hungary, vhorvath@mail.bme.hu
Bibliografia
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  • [14] Shim S.E., Yang S., Jin M.J., Chang Y.H., Choe S., Effect of the polymerization parameters on the morphology and spherical particle size of poly(styrene-co-divinylbenzene) prepared by precipitation polymerization, Colloid Polym. Sci., 2004, 283, 41-48.
  • [15] Horvath V., Lorantfy B., Toth B., Bognar J., Laszlo K., Horvai G., Preparation of terbutylazine imprinted polymer microspheres using viscous polymerization solvents, J. Sep. Sci., 2009, 32, 3347-3358.[Crossref][WoS]
  • [16] Renkecz T., Laszlo K., Horvath V., In situ synthesis of molecularly imprinted nanoparticles in porous support membranes using high-viscosity polymerization solvents, J. Mol. Recognit., 2012, 25, 320-329.[Crossref][WoS]
  • [17] Hansen C.M., Hansen Solubility Paramers: A User‘s Handbook, 2nd ed., CRC Press, Boca Raton, 2007.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_molim-2014-0001
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