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2012 | 1 | 35-40
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Twenty years since‘antibody mimics’by molecular imprinting were first proposed: A critical perspective

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In February 1993, the group of Klaus Mosbach published their milestone study in Nature where, for the first time, non-covalent molecular imprints were employed in a competitive binding assay. In this seminal piece of work, and also for the first time, they refer to molecularly imprinted polymers as being ‘antibody mimics’ and hypothesised that these synthetic materials could one day provide ‘a useful, general alternative to antibodies’. This perspective article examines how far we have come in the 20 years since this publication in terms of realising this hypothesis and poses the question of whether we actually need molecularly imprinted polymers to be a general alternative to antibodies.

Opis fizyczny
  • Cardiff School of Pharmacy
    and Pharmaceutical Sciences,
    Cardiff University, King Edward VII Avenue,
    Cardiff, CF10 3NB, United Kingdom
  • Department of Chemistry and Chemical
    Engineering, Queen’s University Belfast,
    David Keir Building, Stranmillis Road,
    Belfast BT9 5AG, United Kingdom
  • Cardiff School of Pharmacy
    and Pharmaceutical Sciences,
    Cardiff University, King Edward VII Avenue,
    Cardiff, CF10 3NB, United Kingdom,
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