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Tytuł artykułu

MicroRNAs are central to osteogenesis: a review with a focus on cardiovascular calcification

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Cardiovascular calcification, manifested by coronary artery calcification and aortic valve stenosis, is a widespread condition that is becoming more common with the aging of the general population. No disease-modifying therapies currently exist for any forms of cardiovascular calcification. A number of similarities exist between pathological calcification in cardiovascular tissue and physiological calcification in bone, termed osteogenesis. MicroRNAs are small noncoding RNAs that have been shown to have multiple effects throughout the cardiovascular system. In this review, we discuss the pre-clinical evidence supporting a role for microRNAs in osteogenesis, with a focus on cardiovascular calcification. The microRNAs with most evidence implicating them in the disease process are the miR-17~92 cluster, miR-23a/27a/24-2 family, miR-26a, miR-29b, the miR-30 family, miR-31, miR-125b, miR-133a, miR-143/145, miR-155, and miR-221/222. We also highlight the limitations of current evidence in this field, such as the lack of studies using high-throughput technologies.
Wydawca
Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2014-05-04
zaakceptowano
2014-10-30
online
2015-03-24
Twórcy
autor
  • OxVALVE Study, Room B15, Level
    0, Cardiac Investigations Annexe, John Radcliffe Hospital, Headley Way,
    Oxford OX3 9DU, United Kingdom
  • Department of Medicine, University of Otago, Dunedin,
    New Zealand, and Research Fellow, Department of Cardiology,
    Oxford University Hospitals, Oxford, United Kingdom
  • Department of Surgery, University of Otago,
    Dunedin, New Zealand
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_micrnat-2014-0005
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