Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
This article reviews the current strategies and challenges of diagnosing pancreatic cystic lesions, and presents an overview of molecular tools that are available to enhance diagnostic accuracy. Specifically, we highlight the emergence of microRNAs (miRNAs) as diagnostic markers. miRNA signatures have been reported for both solid tissue and biofluid specimens, including cyst fluid, collected from patients with solid and cystic pancreatic lesions. These miRNA signatures offer the opportunity to improve molecular characterization of pancreatic lesions, to help guide clinical management through early diagnosis and informed prognosis, and to provide novel therapeutic targets for pancreatic cancer.
Słowa kluczowe
microRNA
miRNAs
pancreatic cystic neoplasms
cystic fluid
Laboratory Developed Test (LDT)
Clinical Laboratory Improvement Amendments (CLIA)
College of American Pathologists (CAP)
mucinous cystic neoplasms (MCN)
intraductal papillary mucinous neoplasms (IPMN)
cystadenomas (SCA)
solid pseudopapillary neoplasm (SPEN)
endoscopic ultrasound (EUS)
Czasopismo
Rocznik
Tom
Numer
Opis fizyczny
Daty
wydano
2014-01-01
otrzymano
2013-06-03
zaakceptowano
2013-07-14
online
2013-10-07
Twórcy
autor
- Brigham and Women’s Hospital, Boston, MA, slee@partners.org
- Asuragen Inc., Austin, TX, aschwarzbach@asuragen.com
autor
- Asuragen Inc., Austin, TX
autor
- Brigham and Women’s Hospital, Boston, MA
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_micrnat-2013-0003