Identification of a novel miRNA targeting CD146 for suppression of angiogenesis

• Autorzy: Sook Hyun Chung , Weiyong Shen , Mark Gillies
• Języki publikacji: EN

Abstrakty

EN

Angiogenesis is the pathological process of forming new blood vessels from pre-existing vessels. It is one of the main features of many conditions such as cancer and inflammatory diseases. MicroRNAs (miRNAs) are small non-coding RNAs that regulate post-transcriptional gene expression. Recent studies have suggested that miRNAs play a significant role in angiogenesis. The study from Wang et al reported a novel angiomiR, miRNA-329, and its negative correlation with CD 146 expression in angiogenesis. These in vitro and in vivo studies introduce an appealing new way of treating angiogenesis by targeting CD146.

Słowa kluczowe

EN

Angiogenesis; MicroRNA; AngiomiR; miRNA--329

• Czasopismo: Non-coding RNAs in Endocrinology
• Rocznik: 2014
• Tom: 1
• Numer: 1

Daty

wydano

2014-07-01

otrzymano

2014-03-13

zaakceptowano

2014-04-29

online

2014-07-26

Twórcy

autor

Sook Hyun Chung

• Macular Research Group, Clinical Ophthalmology and Eye Health, Save Sight Institute, The University of Sydney, Sydney, Australia,

autor

Weiyong Shen

• Macular Research Group, Clinical Ophthalmology and Eye Health, the University of Sydney, Sydney, Australia

autor

Mark Gillies

• Macular Research Group, Clinical Ophthalmology and Eye Health, the University of Sydney, Sydney, Australia

Bibliografia

• [1] De Falco, S., Antiangiogenesis therapy: an update after the first decade. Korean J Intern Med, 2014. 29(1): p. 1-11.[Crossref][PubMed]
• [2] Crino, L. and G. Metro, Therapeutic options targeting angiogenesis in nonsmall cell lung cancer. Eur Respir Rev, 2014. 23(131): p. 79-91.
• [3] Shord, S.S., et al., Understanding and managing the possible adverse effects associated with bevacizumab. Am J Health Syst Pharm, 2009. 66(11): p. 999-1013.[WoS][Crossref][PubMed]
• [4] Wang, S. and E.N. Olson, AngiomiRs--key regulators of angiogenesis. Curr Opin Genet Dev, 2009. 19(3): p. 205-11.[PubMed][WoS][Crossref]
• [5] Wang, S., et al., The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell, 2008. 15(2): p. 261-71.
• [6] Kuehbacher, A., C. Urbich, and S. Dimmeler, Targeting microRNA expression to regulate angiogenesis. Trends Pharmacol Sci, 2008. 29(1): p. 12-5.[Crossref][WoS][PubMed]
• [7] Rupaimoole, R., et al., MicroRNA therapeutics: principles, expectations, and challenges. Chin J Cancer, 2011. 30(6): p. 368-70.[Crossref]
• [8] Wang, P., et al., MicroRNA 329 suppresses angiogenesis by targeting CD146. Molecular and cellular biology, 2013. 33(18): p. 3689-99.
• [9] Bu, P., et al., Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kappaB activation. Molecular cancer therapeutics, 2006. 5(11): p. 2872-8.
• [10] Kang, Y., et al., Knockdown of CD146 reduces the migration and proliferation of human endothelial cells. Cell research, 2006. 16(3): p. 313-8.

Identyfikatory

DOI

10.2478/micrnado-2014-0001